Spirina L V, Kondakova I V, Koval' V D, Kolomiets L A, Chernyshova A L, Choinzonov E L, Sharova N P
Institute of Oncology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
Bull Exp Biol Med. 2012 Aug;153(4):501-4. doi: 10.1007/s10517-012-1751-3.
The development of endometrial cancer is related to the status of the intracellular proteasome system. Total proteasome activity and pools 26S and 20S activities are higher in tumor tissue than in intact endometrium, and their composition is different. The expression of α1α2α3α5α6α7 is lower in endometrial cancer tissue in comparison with intact endometrium and the content of immune subunits LMP7, LMP2, and PA28β is increased. Total proteasome activity depends on the disease stage.
子宫内膜癌的发生发展与细胞内蛋白酶体系统的状态有关。肿瘤组织中的总蛋白酶体活性以及26S和20S蛋白酶体活性库均高于完整子宫内膜，且其组成不同。与完整子宫内膜相比，子宫内膜癌组织中α1α2α3α5α6α7的表达较低，而免疫亚基LMP7、LMP2和PA28β的含量增加。总蛋白酶体活性取决于疾病分期。
