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乳牙牙髓间充质细胞:细胞表型及其在骨组织工程中应用可能性的初步评估

Mesenchymal cells of the decidual tooth pulp: cytophenotype and initial evaluation of possibility of their use in bone tissue engineering.

作者信息

Vakhrushev I V, Suzdaltseva Yu G, Burunova V V, Karalkin P A, Lupatov A Yu, Yarygin K N

机构信息

V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2010 Jul;149(1):161-6. doi: 10.1007/s10517-010-0897-0.

Abstract

Cultures of mesenchymal cells from human decidual tooth pulp were derived. The phenotype and capacity to osteogenic and adipogenic differentiation of these cells are close to those of bone marrow mesenchymal stem cells. Decidual tooth pulp mesenchymal cells populate biodegraded polylactide scaffolds and hence, can be used for the creation of tissue engineering transplants for bone defect repair. Storage of decidual tooth pulp mesenchymal cells in the stem cell cryobanks together with umbilical blood will appreciably extent the periods of age for collection of juvenile autologous stem cells for use throughout the life span.

摘要

获得了来自人乳牙牙髓的间充质细胞培养物。这些细胞的表型以及成骨和成脂分化能力与骨髓间充质干细胞相近。乳牙牙髓间充质细胞可在生物降解聚丙交酯支架中生长,因此可用于构建组织工程移植物以修复骨缺损。将乳牙牙髓间充质细胞与脐血一同储存在干细胞库中,将显著延长采集幼年自体干细胞以供终身使用的年龄期限。

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