低密度脂蛋白中丙二醛依赖性修饰与胆固醇含量之间的相互关系。

Interrelation between malonyl dialdehyde-dependent modification and cholesterol content in low-density lipoproteins.

作者信息

Tikhaze A K, Viigimaa M, Konovalova G G, Kumskova E M, Abina E A, Zemtsovskaya G, Yanushevskaya E V, Vlasik T N, Lankin V Z

机构信息

Russian Cardiology Research-and-Production Complex, Russian Medical Technologies, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2010 Aug;149(2):184-6. doi: 10.1007/s10517-010-0903-6.

DOI:10.1007/s10517-010-0903-6

PMID:21113487

Abstract

Epidemiological study of an independent representative sample of population revealed a strong positive correlation between the content of oxidized (MDA-modified) LDL and concentration of atherosclerosis biomarkers (total cholesterol and LDL cholesterol) in blood plasma from 348 probands. The correlation between these parameters was more significant in atherosclerotic patients, but was less pronounced in probands with diabetes mellitus. The correlation between the concentration of atherosclerosis markers and content of MDA was absent in probands with diabetes mellitus. These data attest to the presence of LDL-modifying agents differing from MDA (e.g., glyoxal and methylglyoxal) in the blood of diabetes mellitus patients. We conclude that the content of MDA-modified LDL can serve as an additional biomarker of atherosclerosis.

摘要

对一个具有独立代表性的人群样本进行的流行病学研究表明，在348名受试者的血浆中，氧化（MDA修饰）低密度脂蛋白（LDL）的含量与动脉粥样硬化生物标志物（总胆固醇和低密度脂蛋白胆固醇）的浓度之间存在强正相关。这些参数之间的相关性在动脉粥样硬化患者中更为显著，但在糖尿病患者中则不太明显。在糖尿病患者中，动脉粥样硬化标志物浓度与MDA含量之间不存在相关性。这些数据证明糖尿病患者血液中存在不同于MDA的LDL修饰剂（如乙二醛和甲基乙二醛）。我们得出结论，MDA修饰的LDL含量可作为动脉粥样硬化的额外生物标志物。