Andersson-Engels S, Johansson J, Stenram U, Svanberg K, Svanberg S
Department of Physics, Lund Institute of Technology, Sweden.
J Photochem Photobiol B. 1990 Mar;4(4):363-9. doi: 10.1016/1011-1344(90)85015-o.
We report on the enhanced demarcation between human atherosclerotic plaques and normal vessel wall obtained using time-resolved detection of laser-induced fluorescence rather than the customary time-integrated monitoring technique. A frequency-doubled mode-locked and cavity-dumped continuous wave dye laser was used for picosecond pulse generation at 320 nm, and photon-counting techniques were employed for the time-resolved signal monitoring from human aorta samples in vitro. Implications for imaging fluorescence angioscopy and spectroscopic guidance in laser ablation of plaque are indicated.
我们报告了通过时间分辨检测激光诱导荧光而非传统的时间积分监测技术，在区分人类动脉粥样硬化斑块与正常血管壁方面取得的增强效果。使用倍频锁模和腔倒空连续波染料激光器在320nm产生皮秒脉冲，并采用光子计数技术对体外人主动脉样本进行时间分辨信号监测。文中指出了其在荧光血管成像和斑块激光消融的光谱引导方面的意义。
