Bogiel Tomasz, Mikucka Agnieszka, Skalski Tomasz, Gospodarek Eugenia
Katedra i Zakład Mikrobiologii, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Mikolaja Kopernika w Toruniu.
Med Dosw Mikrobiol. 2010;62(3):221-9.
P. aeruginosa rods are dangerous pathogens mainly responsible for nosocomial infections of different localization. Resistance to carbapenems, observed among them, is a serious threat due to ability to be transmitted between bacterial species. The aim of our study was to retrospectively evaluate the frequency of isolation and susceptibility to antibiotics of imipenem- and meropenem-resistant P. aeruginosa strains isolated between 1998 and 2009 from patients of University Hospital No 1 of dr A. Jurasz in Bydgoszcz. Study shows increasing number of isolation that type of strains from 19 in 1998 to 144 in 2009. Among all isolated P. aeruginosa strains majority was obtained from patients of the Intensive Care Units, Rehabilitation and Surgery Clinics. Examined strains of P. aeruginosa rods were mainly isolated from urine (20.5%), bronchoalveolar lavage (17.7%) and wound swabs (14.5%) samples. The isolates demonstrated frequently resistance to carbenicillin (> or 66.7%), ticarcillin (> or = 72.7%) and cefotaxime (> or = 75.6%). The lowest rate of resistant strains was observed in case of ceftazidime (< or = 68.8%), aztreonam (< or = 47.4%) and colistin (< or = 1.7%) suggesting the highest activity of that antimicrobials against infections caused by examined strains.
铜绿假单胞菌杆状菌是主要导致不同部位医院感染的危险病原体。在它们之中观察到的对碳青霉烯类抗生素的耐药性，由于其能够在细菌物种之间传播，构成了严重威胁。我们研究的目的是回顾性评估1998年至2009年间从比得哥什市A. 尤拉什博士第一大学医院患者中分离出的耐亚胺培南和耐美罗培南铜绿假单胞菌菌株的分离频率及对抗生素的敏感性。研究表明，这类菌株的分离数量不断增加，从1998年的19株增加到2009年的144株。在所有分离出的铜绿假单胞菌菌株中，大多数来自重症监护病房、康复科和外科诊所的患者。所检测的铜绿假单胞菌杆状菌菌株主要从尿液（20.5%）、支气管肺泡灌洗（17.7%）和伤口拭子（14.5%）样本中分离得到。这些分离株经常对羧苄青霉素（>或66.7%）、替卡西林（>或=72.7%）和头孢噻肟（>或=75.6%）耐药。在头孢他啶（<或=68.8%）、氨曲南（<或=47.4%）和多粘菌素（<或=1.7%）的情况下，观察到耐药菌株的比例最低，这表明这些抗菌药物对所检测菌株引起的感染具有最高活性。
