• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

临床分离株毒力因子编码基因与基因型分布比较

Comparison of Virulence-Factor-Encoding Genes and Genotype Distribution amongst Clinical Strains.

机构信息

Microbiology Department, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-094 Bydgoszcz, Poland.

Clinical Microbiology Laboratory, Doctor Antoni Jurasz University Hospital No. 1 in Bydgoszcz, 85-094 Bydgoszcz, Poland.

出版信息

Int J Mol Sci. 2023 Jan 9;24(2):1269. doi: 10.3390/ijms24021269.

DOI:10.3390/ijms24021269
PMID:36674786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9863696/
Abstract

is an opportunistic pathogen encoding several virulence factors in its genome, which is well-known for its ability to cause severe and life-threatening infections, particularly among cystic fibrosis patients. The organism is also a major cause of nosocomial infections, mainly affecting patients with immune deficiencies and burn wounds, ventilator-assisted patients, and patients affected by other malignancies. The extensively reported emergence of multidrug-resistant (MDR) strains poses additional challenges to the management of infections. The aim of this study was to compare the incidence rates of selected virulence-factor-encoding genes and the genotype distribution amongst clinical multidrug-sensitive (MDS) and MDR strains. The study involved 74 MDS and 57 MDR strains and the following virulence-factor-encoding genes: , , , , , and . The genotype distribution, with respect to the antimicrobial susceptibility profiles of the strains, was also analyzed. The and genes were present amongst several strains, including all the MDR , suggesting that their presence might be used as a marker for diagnostic purposes. A wide variety of genotype distributions were observed among the investigated isolates, with the MDS and MDR strains exhibiting, respectively, 18 and 9 distinct profiles. A higher prevalence of genes determining the virulence factors in the MDR strains was observed in this study, but more research is needed on the prevalence and expression levels of these genes in additional MDR strains.

摘要

是一种机会性病原体，其基因组中编码了几种毒力因子，它以引起严重和危及生命的感染而闻名，特别是在囊性纤维化患者中。该生物体也是医院获得性感染的主要原因，主要影响免疫缺陷和烧伤患者、呼吸机辅助患者以及受其他恶性肿瘤影响的患者。广泛报道的多药耐药（MDR）菌株的出现给感染的管理带来了额外的挑战。本研究旨在比较选定的毒力因子编码基因的发生率和临床多药敏感（MDS）和 MDR 菌株之间的基因型分布。该研究涉及 74 株 MDS 和 57 株 MDR 菌株，以及以下毒力因子编码基因：、、、、、和。还分析了与菌株的抗菌药物敏感性谱相对应的基因型分布。多个 菌株中存在 和 基因，包括所有 MDR ，这表明它们的存在可能被用作诊断目的的标志物。在所研究的分离株中观察到多种基因型分布，MDS 和 MDR 菌株分别表现出 18 和 9 种不同的图谱。在本研究中观察到 MDR 菌株中决定毒力因子的基因的更高流行率，但需要对这些基因在其他 MDR 菌株中的流行率和表达水平进行更多研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba43/9863696/00a942879ccc/ijms-24-01269-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba43/9863696/12637cb36a89/ijms-24-01269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba43/9863696/96da5103f702/ijms-24-01269-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba43/9863696/894e5bfae685/ijms-24-01269-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba43/9863696/fdb99bf9544b/ijms-24-01269-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba43/9863696/00a942879ccc/ijms-24-01269-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba43/9863696/12637cb36a89/ijms-24-01269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba43/9863696/96da5103f702/ijms-24-01269-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba43/9863696/894e5bfae685/ijms-24-01269-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba43/9863696/fdb99bf9544b/ijms-24-01269-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba43/9863696/00a942879ccc/ijms-24-01269-g005.jpg

相似文献

1
Comparison of Virulence-Factor-Encoding Genes and Genotype Distribution amongst Clinical Strains.临床分离株毒力因子编码基因与基因型分布比较
Int J Mol Sci. 2023 Jan 9;24(2):1269. doi: 10.3390/ijms24021269.
2
Decoding Genetic Features and Antimicrobial Susceptibility of Strains Isolated from Bloodstream Infections.解析血流感染分离株的遗传特征和抗菌药敏性
Int J Mol Sci. 2022 Aug 16;23(16):9208. doi: 10.3390/ijms23169208.
3
Diversity of virulence genes in multidrug resistant Pseudomonas aeruginosa isolated from burn wound infections.多药耐药铜绿假单胞菌致烧伤感染的毒力基因多样性。
Microb Pathog. 2018 Feb;115:251-256. doi: 10.1016/j.micpath.2017.12.052. Epub 2017 Dec 19.
4
The Prevalence of Exoenzyme S Gene in Multidrug-Sensitive and Multidrug-Resistant Pseudomonas aeruginosa Clinical Strains.多药敏感和多药耐药铜绿假单胞菌临床菌株中外毒素S基因的流行情况
Pol J Microbiol. 2017 Dec 4;66(4):427-431. doi: 10.5604/01.3001.0010.6500.
5
Coordination of las regulated virulence factors with Multidrug-Resistant and extensively drug-resistant in superbug strains of P. aeruginosa.铜绿假单胞菌超级菌株中 las 调节毒力因子与多药耐药和广泛耐药的协调作用。
Mol Biol Rep. 2020 Jun;47(6):4131-4143. doi: 10.1007/s11033-020-05559-4. Epub 2020 May 30.
6
Reduced expression of virulence factors in multidrug-resistant Pseudomonas aeruginosa strains.多重耐药铜绿假单胞菌毒力因子表达降低。
Arch Microbiol. 2010 Jan;192(1):79-84. doi: 10.1007/s00203-009-0528-1. Epub 2009 Dec 4.
7
Relationship between antibiotic resistance, biofilm formation, genes coding virulence factors and source of origin of clinical strains.临床菌株的抗生素耐药性、生物膜形成、编码毒力因子基因与来源之间的关系。
Ann Agric Environ Med. 2021 Jun 14;28(2):306-313. doi: 10.26444/aaem/122682. Epub 2020 Jun 4.
8
Influence of virulence genotype and resistance profile in the mortality of Pseudomonas aeruginosa bloodstream infections.铜绿假单胞菌血流感染的毒力基因型和耐药谱对死亡率的影响。
Clin Infect Dis. 2015 Feb 15;60(4):539-48. doi: 10.1093/cid/ciu866. Epub 2014 Nov 6.
9
Prevalence of antibiotic resistance and virulent factors in nosocomial clinical isolates of Pseudomonas aeruginosa from Panamá.巴拿马医院分离的铜绿假单胞菌的抗生素耐药性和毒力因子的流行情况。
Braz J Infect Dis. 2021 Jan-Feb;25(1):101038. doi: 10.1016/j.bjid.2020.11.003. Epub 2020 Dec 4.
10
Resistance patterns, virulence determinants, and biofilm genes of multidrug-resistant Pseudomonas aeruginosa isolated from fish and fish handlers.从鱼类和鱼类处理者中分离的多药耐药铜绿假单胞菌的耐药模式、毒力决定因素和生物膜基因。
Sci Rep. 2024 Oct 14;14(1):24063. doi: 10.1038/s41598-024-73917-4.

引用本文的文献

1
Impact of biofilm formation by different sequence types on treating lower limb vascular infections.不同序列类型的生物膜形成对治疗下肢血管感染的影响。
Curr Res Microb Sci. 2025 Apr 11;8:100379. doi: 10.1016/j.crmicr.2025.100379. eCollection 2025.
2
The virulence trait and genotype distribution amongst the Pseudomonas aeruginosa clinical strains.铜绿假单胞菌临床菌株的毒力特征及基因型分布。
BMC Microbiol. 2025 Feb 20;25(1):82. doi: 10.1186/s12866-025-03754-6.
3
Phages ZC01 and ZC03 require type-IV pilus for infection and have a potential for therapeutic applications.

本文引用的文献

1
Antibiotic Resistance in Pseudomonas.铜绿假单胞菌的抗生素耐药性。
Adv Exp Med Biol. 2022;1386:117-143. doi: 10.1007/978-3-031-08491-1_5.
2
Decoding Genetic Features and Antimicrobial Susceptibility of Strains Isolated from Bloodstream Infections.解析血流感染分离株的遗传特征和抗菌药敏性
Int J Mol Sci. 2022 Aug 16;23(16):9208. doi: 10.3390/ijms23169208.
3
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics.铜绿假单胞菌：发病机制、毒力因子、抗生素耐药性、与宿主的相互作用、技术进展和新兴治疗方法。
噬菌体ZC01和ZC03感染需要IV型菌毛，具有治疗应用潜力。
Microbiol Spectr. 2024 Oct 29;12(12):e0152724. doi: 10.1128/spectrum.01527-24.
4
Prevalence of the virulence genes and their correlation with carbapenem resistance amongst the Pseudomonas aeruginosa strains isolated from a tertiary hospital in China.中国一家三级医院分离的铜绿假单胞菌的毒力基因流行情况及其与碳青霉烯类耐药性的相关性。
Antonie Van Leeuwenhoek. 2023 Dec;116(12):1395-1406. doi: 10.1007/s10482-023-01869-2. Epub 2023 Oct 17.
Signal Transduct Target Ther. 2022 Jun 25;7(1):199. doi: 10.1038/s41392-022-01056-1.
4
Pathogenesis of the Biofilm: A Review.生物膜的发病机制：综述
Pathogens. 2022 Feb 27;11(3):300. doi: 10.3390/pathogens11030300.
5
Genomic and Metabolic Characteristics of the Pathogenicity in .**解析**：“Genomic”译为“基因组的”，“Metabolic”译为“新陈代谢的”，“Pathogenicity”译为“致病性”。 **译文**：. 的致病性的基因组和代谢特征
Int J Mol Sci. 2021 Nov 29;22(23):12892. doi: 10.3390/ijms222312892.
6
Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase.具有双重活性的细菌磷脂酶 C：磷脂酰胆碱酶和神经鞘磷脂酶。
FEBS Open Bio. 2021 Dec;11(12):3262-3275. doi: 10.1002/2211-5463.13320. Epub 2021 Nov 8.
7
Virulence factors in multidrug (MDR) and Pan-drug resistant (XDR) Pseudomonas aeruginosa: a cross-sectional study of isolates recovered from ocular infections in a high-incidence setting in southern India.多重耐药（MDR）和泛耐药（XDR）铜绿假单胞菌的毒力因子：一项对印度南部高发病区眼部感染分离株的横断面研究。
J Ophthalmic Inflamm Infect. 2021 Sep 28;11(1):36. doi: 10.1186/s12348-021-00268-w.
8
No Correlation between Biofilm Formation, Virulence Factors, and Antibiotic Resistance in : Results from a Laboratory-Based In Vitro Study.生物膜形成、毒力因子与抗生素耐药性之间无相关性：一项基于实验室的体外研究结果
Antibiotics (Basel). 2021 Sep 20;10(9):1134. doi: 10.3390/antibiotics10091134.
9
Relationship between antibiotic resistance, biofilm formation, genes coding virulence factors and source of origin of clinical strains.临床菌株的抗生素耐药性、生物膜形成、编码毒力因子基因与来源之间的关系。
Ann Agric Environ Med. 2021 Jun 14;28(2):306-313. doi: 10.26444/aaem/122682. Epub 2020 Jun 4.
10
Pseudomonas aeruginosa device associated - healthcare associated infections and its multidrug resistance at intensive care unit of University Hospital: polish, 8.5-year, prospective, single-centre study.铜绿假单胞菌相关医疗器械- 医源性感染及其在大学医院重症监护病房的多药耐药性：波兰，8.5 年，前瞻性，单中心研究。
BMC Infect Dis. 2021 Feb 16;21(1):180. doi: 10.1186/s12879-021-05883-5.