Northwestern University, Feinberg School of Medicine, 303 E Superior Street, Chicago, IL 60611, USA.
Am J Reprod Immunol. 2011 Mar;65(3):279-83. doi: 10.1111/j.1600-0897.2010.00934.x. Epub 2010 Nov 28.
HIV sexual transmission via the male genital tract remains poorly defined. Male circumcision was shown to reduce female-to-male transmission in Africa, providing a clue that the foreskin plays a role in the route of transmission. Scientific data in four categories relating to how the foreskin might affect HIV transmission is summarized: (i) surface area, (ii) microbiologic environment, (iii) HIV-1-susceptible cells, and (iv) tissue structure. The relative contribution of each of these areas is yet unknown, and further studies will be crucial in understanding how male circumcision affects HIV transmission in men.
HIV 通过男性生殖器官的性传播仍未得到充分定义。在非洲，男性割礼被证明可以降低女性向男性的传播，这提示包皮在传播途径中发挥了作用。本文总结了与包皮可能影响 HIV 传播有关的四类科学数据：（i）表面积，（ii）微生物环境，（iii）HIV-1 易感细胞，和（iv）组织结构。这些领域中每一个的相对贡献尚不清楚，进一步的研究对于了解男性割礼如何影响男性的 HIV 传播至关重要。
