Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco.
BMC Endocr Disord. 2010 Nov 29;10:19. doi: 10.1186/1472-6823-10-19.
The most common cause of hypopituitarism is pituitary adenoma. However, in the case of suprasellar masses different etiologies are possible. We report an unusual case of primary suprasellar lymphoma presented with hypopituitarism.
A 26 year old woman presented with amenorrhea, galactorrhea and neurological disorders. Also, the laboratory work-up revealed partial hypopituitarism. The magnetic resonance imaging of the head showed a suprasellar mass. A presumptive diagnosis of granulomatous processes was made and the patient was given steroid therapy. Repeated brain MRI detected new lesions in the brain with regression of the suprasellar mass. Stereotactic biopsy of the paraventricular lesion revealed the diagnosis of B-cell lymphoma.
This case presentation reports a rare cause of hypopituitarism. Primary suprasellar lymphoma is extremely rare and represented a real diagnostic challenge. Besides, suprasellar masses are varied in aetiology and can present diagnostic problems for a radiologist. Also, because of the increased incidence of PCNSL, lymphoma must be kept in mind in the differential diagnosis of lesions in the suprasellar region.
垂体功能减退症最常见的原因是垂体腺瘤。然而，鞍上肿块的病因可能不同。我们报告了一例罕见的原发性鞍上淋巴瘤表现为垂体功能减退症的病例。
一名 26 岁女性因闭经、溢乳和神经功能障碍就诊。此外，实验室检查显示部分垂体功能减退症。头部磁共振成像显示鞍上肿块。推测为肉芽肿性病变，给予患者类固醇治疗。反复脑部 MRI 检查发现脑部有新的病变，鞍上肿块消退。室旁病变的立体定向活检显示 B 细胞淋巴瘤的诊断。
本病例报告了一种罕见的垂体功能减退症病因。原发性鞍上淋巴瘤极为罕见，对诊断构成了真正的挑战。此外，鞍上肿块的病因多种多样，可能给放射科医生带来诊断问题。此外，由于 PCNSL 的发病率增加，在鞍上区域病变的鉴别诊断中必须考虑淋巴瘤。
