Naveh N, Belkin M, Ben-Chaim O, Weissman C, Treister G
Maurice and Gabriela Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel.
Ophthalmic Res. 1990;22(1):3-11. doi: 10.1159/000266995.
We measured prostaglandin E2 (PGE2) and prostacyclin levels in the vitreous bodies of 5 eyes of patients with diabetic retinopathy complicated by rhegmatogenous retinal detachment (RRD) and compared them with the corresponding levels in 9 nondiabetic eyes with the same condition as well as with 10 control eyes of deceased patients with no known ocular pathology. We also studied the effect of surgical retinal reattachment on vitreal PGE2 and prostacyclin levels in 4 eyes. Vitreal samples from both nondiabetic and diabetic eyes with RRD were obtained during vitrectomy, while samples from deceased subjects (controls) were obtained 2-6 h after death. Vitreal PGE2 and prostacyclin levels in the control eyes approximated plasma levels (79.9 +/- 20.5 and 124.5 +/- 38.5 pg/ml, means +/- SD, respectively), while RRD in the nondiabetic eyes was associated with increased levels of both PGE2 and prostacyclin (3,170 +/- 3,024 and 467 +/- 283 pg/ml, respectively). In the diabetic eyes with diabetic retinopathy complicated by RRD, all of which underwent retinal photocoagulation, PGE2 and prostacyclin levels were 2-4 times lower than those of the nondiabetic eyes with detached retina. Following surgical retinal reattachment, vitreal levels of both components in diabetics and nondiabetics showed a reduction suggesting that the surgical procedure for obtaining vitreal samples was not the cause for elevated prostaglandin levels in the eyes with detached retina. We showed that RRD is associated with an excessive accumulation of PGE2 and prostacyclin in the vitreous, which is higher in nondiabetic than in diabetic eyes, indicating that diabetic retinopathy in laser-treated eyes might lead to reduced vitreal levels of these metabolites.
我们测量了5例糖尿病视网膜病变合并孔源性视网膜脱离（RRD）患者眼玻璃体内的前列腺素E2（PGE2）和前列环素水平，并将其与9例患有相同病症的非糖尿病患者眼以及10例无已知眼部病变的已故患者的对照眼的相应水平进行比较。我们还研究了4只眼中视网膜手术复位对玻璃体内PGE2和前列环素水平的影响。患有RRD的非糖尿病和糖尿病患者眼的玻璃体液样本在玻璃体切除术中获取，而来自已故受试者（对照）的样本在死后2 - 6小时获取。对照眼中玻璃体内的PGE2和前列环素水平接近血浆水平（分别为79.9±20.5和124.5±38.5 pg/ml，均值±标准差），而非糖尿病患者眼中的RRD与PGE2和前列环素水平升高相关（分别为3170±3024和467±283 pg/ml）。在患有糖尿病视网膜病变合并RRD的糖尿病患者眼中，所有患者均接受了视网膜光凝治疗，PGE2和前列环素水平比视网膜脱离的非糖尿病患者眼低2 - 4倍。视网膜手术复位后，糖尿病和非糖尿病患者眼中这两种成分的玻璃体内水平均降低，这表明获取玻璃体液样本的手术操作并非视网膜脱离患者眼中前列腺素水平升高的原因。我们发现RRD与玻璃体内PGE2和前列环素的过度积聚有关，非糖尿病患者眼中的积聚高于糖尿病患者眼，这表明接受激光治疗的糖尿病视网膜病变可能导致这些代谢产物的玻璃体内水平降低。
