Radiation Oncology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Crit Rev Oncol Hematol. 2012 Dec;84 Suppl 1:e75-8. doi: 10.1016/j.critrevonc.2010.10.001. Epub 2010 Nov 5.
Patients with node negative and large primary tumors ≥5cm comprise a rare entity of breast cancer patients for which clear management guidelines are not available. Data about the rates of loco-regional failures (LRF) in this patient population are scarce and reporting widely varying observations. Post Mastectomy Radiation Therapy (PMRT) for this group of patients is controversial. In this review we examined the available literature discussing the LRF rates in this clinical setting and the value of adding PMRT in their management.
对于淋巴结阴性且原发肿瘤较大（≥5cm）的患者，目前尚缺乏明确的管理指南。关于这部分患者局部区域复发（LRF）率的数据很少，且报道结果差异很大。对于这组患者，是否行乳房切除术术后放疗（PMRT）存在争议。在本综述中，我们查阅了相关文献，讨论了该临床情况下的 LRF 率，以及在其管理中添加 PMRT 的价值。
