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Recent Developments in Radiation Oncology: An Overview of Individualised Treatment Strategies in Breast Cancer.放射肿瘤学的最新进展：乳腺癌个体化治疗策略概述
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2
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本文引用的文献

1
Tumour bed boost radiotherapy for women after breast-conserving surgery.保乳手术后女性的瘤床加量放疗。
Cochrane Database Syst Rev. 2017 Nov 6;11(11):CD011987. doi: 10.1002/14651858.CD011987.pub2.
2
Left-sided breast cancer and risks of secondary lung cancer and ischemic heart disease : Effects of modern radiotherapy techniques.左侧乳腺癌与继发性肺癌和缺血性心脏病风险：现代放疗技术的影响。
Strahlenther Onkol. 2018 Mar;194(3):196-205. doi: 10.1007/s00066-017-1213-y. Epub 2017 Sep 15.
3
Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial.早期乳腺癌保乳手术后部分乳房放疗的疗效（英国 IMPORT LOW 试验）：一项多中心、随机、对照、3 期、非劣效性临床试验的 5 年结果。
Lancet. 2017 Sep 9;390(10099):1048-1060. doi: 10.1016/S0140-6736(17)31145-5. Epub 2017 Aug 2.
4
Hypofractionated Postmastectomy Radiation Therapy Is Safe and Effective: First Results From a Prospective Phase II Trial.保乳术后大分割放疗安全有效：一项前瞻性II期试验的初步结果
J Clin Oncol. 2017 Jun 20;35(18):2037-2043. doi: 10.1200/JCO.2016.70.7158. Epub 2017 May 1.
5
Hypofractionated whole breast radiotherapy in breast conservation for early-stage breast cancer: a systematic review and meta-analysis of randomized trials.早期乳腺癌保乳治疗中短程大分割全乳放疗：随机试验的系统评价和荟萃分析
Breast Cancer Res Treat. 2017 Apr;162(3):409-417. doi: 10.1007/s10549-017-4118-7. Epub 2017 Feb 3.
6
Neoadjuvant radiotherapy followed by mastectomy and immediate breast reconstruction : An alternative treatment option for locally advanced breast cancer.新辅助放疗后行乳房切除术及即刻乳房重建：局部晚期乳腺癌的一种替代治疗选择。
Strahlenther Onkol. 2017 Apr;193(4):324-331. doi: 10.1007/s00066-017-1100-6. Epub 2017 Jan 25.
7
Current controversies in radiotherapy for breast cancer.乳腺癌放射治疗中的当前争议
Radiat Oncol. 2017 Jan 23;12(1):25. doi: 10.1186/s13014-017-0766-3.
8
Intraoperative radiotherapy (IORT) as boost in breast cancer.术中放疗用于乳腺癌的剂量增强治疗
Radiat Oncol. 2017 Jan 19;12(1):23. doi: 10.1186/s13014-016-0749-9.
9
Late side-effects and cosmetic results of accelerated partial breast irradiation with interstitial brachytherapy versus whole-breast irradiation after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: 5-year results of a randomised, controlled, phase 3 trial.保乳手术后低危型女性乳腺浸润性癌和原位癌的加速部分乳腺照射与全乳照射的晚期副反应和美容效果：一项随机、对照、3 期临床试验的 5 年结果。
Lancet Oncol. 2017 Feb;18(2):259-268. doi: 10.1016/S1470-2045(17)30011-6. Epub 2017 Jan 14.
10
Trends in use and outcome of postoperative radiotherapy following mastectomy: A population-based study.乳腺癌根治术后放疗使用及效果的变化趋势：一项基于人群的研究。
Radiother Oncol. 2017 Jan;122(1):2-10. doi: 10.1016/j.radonc.2016.08.018. Epub 2016 Sep 15.

放射肿瘤学的最新进展：乳腺癌个体化治疗策略概述

Recent Developments in Radiation Oncology: An Overview of Individualised Treatment Strategies in Breast Cancer.

作者信息

Pazos Montserrat, Schönecker Stephan, Reitz Daniel, Rogowski Paul, Niyazi Maximilian, Alongi Filippo, Matuschek Christiane, Braun Michael, Harbeck Nadia, Belka Claus, Corradini Stefanie

机构信息

Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.

Department of Radiation Oncology, Sacro Cuore Don Calbria Negrar, Verona, Italy.

出版信息

Breast Care (Basel). 2018 Aug;13(4):285-291. doi: 10.1159/000488189. Epub 2018 May 24.

DOI:10.1159/000488189
PMID:30319331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6170912/
Abstract

Radiation therapy (RT) for breast cancer has dramatically changed over the past years, leading to individualized risk-adapted treatment strategies. Historically, the choice of RT regimen was limited to conventional fractionation protocols using standard tangential fields. Nowadays, technological and technical improvements in modern RT have added a variety of other RT modalities, different fractionation schedules, and individualised treatment volumes to the portfolio of breast RT. This review aims to give a short overview on the main topics which have recently found their way into clinical practice: hypofractionated treatment protocols, accelerated partial breast irradiation (APBI) for low-risk patients, deep inspiration breath hold (DIBH) for maximal heart protection, extent of regional nodal irradiation for high-risk patients, and the implementation of new radiation techniques such as intensity modulated RT (IMRT) and volumetric modulated RT (VMAT).

摘要

在过去几年中，乳腺癌的放射治疗（RT）发生了巨大变化，从而产生了个体化的风险适应性治疗策略。从历史上看，RT方案的选择仅限于使用标准切线野的传统分割方案。如今，现代RT的技术改进为乳腺RT的方案增加了多种其他RT模式、不同的分割方案以及个体化的治疗体积。本综述旨在简要概述最近已应用于临床实践的主要主题：低分割治疗方案、针对低风险患者的加速部分乳腺照射（APBI）、为最大程度保护心脏的深吸气屏气（DIBH）、针对高风险患者的区域淋巴结照射范围，以及新放射技术如调强放疗（IMRT）和容积调强放疗（VMAT）的应用。