Musabajeva L I, Lavrenkov K A, Lisin V A
Wissenschaftliches onkologisches Forschungsinstitut, Tomskes wissenschaftliches Zentrum, AdMW der UdSSR.
Radiobiol Radiother (Berl). 1990;31(1):61-7.
In the present information results of clinical studies are represented to show the effectiveness of therapy with 6.3 MeV fast neutrons in 45 patients with superficial tumors in head and neck area. The reaction of tumor and of normal tissue was studied in dependence on different physical and biological factors. Two variants of neutron therapy planning were estimated by means of mathematical models of a factor of time-dose-fractionation for neutron (TDFN) from clinical point of view. Results of changes in oxygen-tension within the tumor are represented in 20 patients with metastases in cervical lymph-nodes during neutron therapy. The obtained data show a correlation of regression and reoxygenation rate of the tumor to its initial volume. The reaction of the tumor in therapy with fast neutrons was studied in dependence on its morphological structure. Complete regression of epidermoid and nonepidermoid cancer types was seen in 42 or 89% of the cases. With corrections for adipose tissue and the extent of dose fraction of fast neutrons the clinical test of the mathematical model of TDFN-factor made discernible that the reaction of normal tissue can be prognosticated quite exactly by means of this model in neutron therapy.
在当前的信息中，展示了临床研究结果，以表明6.3兆电子伏快中子治疗45例头颈部浅表肿瘤患者的疗效。研究了肿瘤和正常组织的反应与不同物理和生物学因素的关系。从临床角度，通过中子时间-剂量-分割因子（TDFN）的数学模型评估了两种中子治疗计划方案。给出了20例颈部淋巴结转移患者在中子治疗期间肿瘤内氧张力变化的结果。所获数据显示肿瘤的消退和再氧合率与其初始体积相关。研究了快中子治疗中肿瘤反应与其形态结构的关系。在42例（占89%）病例中观察到表皮样癌和非表皮样癌类型完全消退。通过对脂肪组织和快中子剂量分割程度进行校正，TDFN因子数学模型的临床试验表明，在中子治疗中借助该模型可以相当准确地预测正常组织的反应。
