School of Medicine, University of Colorado Denver, Denver, CO, USA.
Int J Sport Nutr Exerc Metab. 2010 Dec;20(6):466-74. doi: 10.1123/ijsnem.20.6.466.
Increasing fat content in an isocaloric diet is associated with positive fat imbalance. Exercise attenuates this process, and the authors hypothesized the attenuation was a result of altered postprandial lipid trafficking.
To investigate the effects of prior exercise and nutritional state on the metabolic fate of dietary fat, a study was designed with 4 treatment arms. Energy-balance modifications (fed or fasted) ± exercise were followed by postexercise feeding of 1-14C oleic acid to Sprague-Dawley rats. Fed rats were fed 6 hr before treatment, whereas fasted rats were fasted for 15 hr before treatment with the primary variable being exercise.
14C content of gastrointestinal tract, plasma, breath, muscle (soleus, vastus lateralis [VL], and extensor digitorum longus), liver, and adipose tissue (retroperitoneal and epididymal) was measured at 5 time points postdose (1, 2, 4, 8, and 24 hr).
Compared with matched unexercised controls, fed rats undergoing acute exercise significantly increased recovery of 14C in breath (p = .005) and plasma (p = .001), and trends of increasing 14C recovery occurred in VL (p = .07) and soleus (p = .06). Acute exercise significantly increased recovery of 14C in breath (p = .003), VL (p = .04), and soleus (p = .03) in the fasted study. Acute exercise significantly decreased the trafficking of dietary tracer into adipose tissue in only the fed study (p < .0001).
Although the effect of acute exercise on trafficking dietary fat away from adipose tissue was greater in the fed group than in the fasted, acute exercise had beneficial effects on adipose tissue's collecting dietary fat when fed or fasted.
在等热量饮食中增加脂肪含量与脂肪正平衡有关。运动可减弱这种作用，作者推测这种减弱是由于餐后脂质转运的改变。
为了研究先前运动和营养状态对膳食脂肪代谢命运的影响，设计了一项具有 4 种处理组的研究。在运动后给予 1-14C 油酸喂养之前，进行能量平衡的改变（进食或禁食）±运动。进食组在治疗前 6 小时进食，而禁食组在治疗前禁食 15 小时，主要变量为运动。
在 5 个时间点（1、2、4、8 和 24 小时）后，测量胃肠道、血浆、呼吸、肌肉（比目鱼肌、股外侧肌和伸趾长肌）、肝脏和脂肪组织（腹膜后和附睾）中的 14C 含量。
与匹配的未运动对照组相比，进行急性运动的进食大鼠显著增加了呼吸（p =.005）和血浆（p =.001）中 14C 的回收，并且 VL（p =.07）和比目鱼肌（p =.06）中 14C 回收的趋势增加。急性运动在禁食研究中显著增加了呼吸（p =.003）、VL（p =.04）和比目鱼肌（p =.03）中 14C 的回收。急性运动仅在进食研究中显著减少了膳食示踪剂向脂肪组织的转运（p <.0001）。
尽管急性运动对进食组中膳食脂肪从脂肪组织转运的影响大于禁食组，但急性运动对进食或禁食时脂肪组织收集膳食脂肪具有有益作用。
