高对映选择性 Mannich 型三组分反应中重氮苯乙酮与醇和亚胺的协同催化。
Cooperative catalysis in highly enantioselective Mannich-type three-component reaction of a diazoacetophenone with an alcohol and an imine.
机构信息
East China Normal University, Institute of Drug Discovery and Development, Department of Chemistry, Shanghai 200062, China.
出版信息
Chem Commun (Camb). 2011 Jan 14;47(2):797-9. doi: 10.1039/c0cc03024d. Epub 2010 Nov 29.
PMID:21116516
Abstract
A highly enantioselective three-component reaction of a diazoacetophenone, an alcohol, and an imine catalyzed cooperatively by Rh(2)(OAc)(4) and BINOL-derived chiral phosphoric acid has been developed for the synthesis of chiral β-amino-α-hydroxyl ketones in good yield with excellent diastereo and enantio selectivity.
摘要
一种高对映选择性的三组分反应，由重氮乙酮、醇和亚胺组成，在 Rh(2)(OAc)(4)和手性磷酸 BINOL 衍生的协同催化下，用于合成手性β-氨基-α-羟基酮，具有优异的非对映选择性和对映选择性，产率良好。
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