手性布朗斯特酸-Rh2(OAc)4协同催化：重氮化合物与醇和亚胺的高对映选择性三组分反应
Cooperative catalysis with chiral Brønsted acid-Rh2(OAc)4: highly enantioselective three-component reactions of diazo compounds with alcohols and imines.
作者信息
Hu Wenhao, Xu Xinfang, Zhou Jing, Liu Wei-Jun, Huang Haoxi, Hu Juan, Yang Liping, Gong Liu-Zhu
机构信息
Department of Chemistry, East China Normal University, Shanghai 200062, China.
出版信息
J Am Chem Soc. 2008 Jun 25;130(25):7782-3. doi: 10.1021/ja801755z. Epub 2008 May 31.
PMID:18512907
Abstract
An asymmetric three-component reaction of diazo compounds and alcohols with imines catalyzed cooperatively by a rhodium complex and a chiral Brønsted acid provides a general and efficient entry to beta-amino-alpha-hydroxyl acid derivatives in high yields with excellent stereoselectivities.
摘要
铑配合物和手性布朗斯特酸协同催化重氮化合物、醇与亚胺的不对称三组分反应，为高产率、高立体选择性地合成β-氨基-α-羟基酸衍生物提供了一种通用且高效的方法。
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