Hematology and Cell Therapy and Foundation for Applied Medical Research, Division of Cancer, University of Navarra, Av. Pío XII 36, Pamplona, Spain.
J Cardiovasc Transl Res. 2011 Apr;4(2):145-53. doi: 10.1007/s12265-010-9246-y. Epub 2010 Nov 30.
In recent years, stem cell treatment of myocardial infarction has elicited great enthusiasm upon scientists and physicians alike, thus making the finding of a suitable cell a compulsory subject for modern medicine. Due to its potential, accessibility and efficiency of harvesting, adipose tissue has become one of the most attractive sources of stem cells for regenerative therapies. The differentiation capacity and the paracrine activity of these cells has made them an optimal candidate for the treatment of a diverse range of diseases from immunological disorders as graft versus host disease to cardiovascular pathologies like peripheral ischemia. In this review, we will focus on the use of stem cells derived from adipose tissue for treatment of myocardial infarction, with special attention to their putative in vivo mechanisms of action.
近年来，干细胞治疗心肌梗死引起了科学家和医生的极大热情，因此寻找合适的细胞成为现代医学的一个必修课题。由于脂肪组织具有潜在性、可及性和高效收获的特点，它已成为再生治疗中最有吸引力的干细胞来源之一。这些细胞的分化能力和旁分泌活性使它们成为治疗多种疾病的理想候选物，从免疫疾病如移植物抗宿主病到心血管疾病如外周缺血。在这篇综述中，我们将重点讨论脂肪组织来源的干细胞在治疗心肌梗死中的应用，特别关注它们在体内的作用机制。
