Kou Yuhui, Zhang Peixun, Yin Xiaofeng, Wei ShaoYin, Wang Yanhua, Zhang Hongbo, Jiang Baoguo
Peking University People's Hospital, Beijing, China.
Artif Cells Blood Substit Immobil Biotechnol. 2011 Aug;39(4):223-7. doi: 10.3109/10731199.2010.533127. Epub 2010 Nov 30.
The effects of the distal nerve degeneration on the regeneration of the collateral sprouts from the proximal nerve stump have been examined. The delayed cross-suture anastomosis technique was used in which the tibial nerve was denervated for 0-8 weeks before cross-suture of the freshly axotomized common peroneal and chronically denervated TIB nerve stumps. There was a remarkable decreasing of the regenerated myelinated axons number after the distal nerve suffered 8 weeks deterioration, suggesting that short-term denervation did not affect the collateral sprouts regeneration but more prolonged denervation profoundly reduced collateral sprouts regenerated in the distal nerve stump.
已对远端神经变性对近端神经残端侧支芽再生的影响进行了研究。采用延迟交叉缝合吻合技术，即新鲜切断坐骨神经后，在将腓总神经和慢性去神经支配的胫神经残端进行交叉缝合之前，将胫神经去神经支配0至8周。远端神经发生8周退变后，再生有髓轴突数量显著减少，这表明短期去神经支配并不影响侧支芽再生，但去神经支配时间延长会显著减少远端神经残端再生的侧支芽。
