Hanson C V, Riggs J L, Lennette E H
J Gen Virol. 1978 Aug;40(2):345-58. doi: 10.1099/0022-1317-40-2-345.
Western equine encephalitis virus, and RNA virus, and herpes simplex virus type I, a DNA virus, were efficiently inactivated in less than I min by exposure to long-wave ultraviolet light (320 to 380 nm) in the presence of several psoralen derivatives. The psoralen photochemical reaction was chosen for study due to its known specificity for nucleic acids. Neither the light nor any of the drugs alone caused appreciable inactivation. The inactivation kinetics and dependence on light intensity and on different derivatives of psoralen were studied. The high solubility of a new aminomethyl psoralen derivative was found to be advantageous in the photochemical inactivation of the RNA virus, but was not in the case of the more easily inactivated DNA virus. Within its limited solubility range trimethylpsoralen was superior to its aminomethyl derivative on a molar basis for the inactivation of both types of viruses under most of the conditions studied.
西部马脑炎病毒（一种RNA病毒）和单纯疱疹病毒I型（一种DNA病毒），在几种补骨脂素衍生物存在的情况下，通过暴露于长波紫外线（320至380纳米），在不到1分钟的时间内被有效灭活。由于补骨脂素光化学反应对核酸具有已知的特异性，因此选择对其进行研究。单独的光或任何一种药物都不会导致明显的灭活。研究了灭活动力学以及对光强度和补骨脂素不同衍生物的依赖性。发现一种新的氨甲基补骨脂素衍生物的高溶解度在RNA病毒的光化学灭活中具有优势，但在更容易灭活的DNA病毒的情况下则不然。在所研究的大多数条件下，在摩尔基础上，三甲补骨脂素在其有限的溶解度范围内比其氨甲基衍生物在两种病毒的灭活方面更具优势。
