Ueda Minoru
Department of Oral and Maxillofacial Surgery, School of Medicine, Nagoya University, Nagoya, Japan.
J Craniofac Surg. 2010 Nov;21(6):1729-32. doi: 10.1097/SCS.0b013e3181f3c78b.
Mucosal epithelial cells have various advantages compared with epidermal cells, such as their high proliferation ability and long biologic activity. The objective of this study was to assess the clinical results after sprayed application of cultured mucosal epithelial autograft (CMEA) suspensions onto deep dermal burn wounds. Ten patients with deep dermal burns were included in a prospective study. The average total-body-surface-area burn was 17.7% (8%-45%). The average Abbreviated Burn Severity Index was 6.3 points (4-9 points). The application of sprayed CMEA suspension was performed onto an average body surface area of 2.05% (0.5%-5%; median, 2%). Eight patients were recruited for clinical follow-up after an average of 10 months (3-18 months). The average Vancouver Scar Scale score at follow-up was 1.5 points (range, 0-5 points). The average period of epithelialization in wound surface was 12.5 days. Our data show that enzymatic and careful surgical debridement and consecutive application of CMEA suspensions using a spray technique result in excellent cosmetic outcomes compared with any other methods.
与表皮细胞相比，黏膜上皮细胞具有多种优势，如高增殖能力和长生物活性。本研究的目的是评估将培养的黏膜上皮自体移植物（CMEA）悬浮液喷洒应用于深度真皮烧伤创面后的临床效果。10例深度真皮烧伤患者纳入前瞻性研究。平均总体表面积烧伤为17.7%（8%-45%）。平均简化烧伤严重程度指数为6.3分（4-9分）。喷洒的CMEA悬浮液平均应用于2.05%的体表面积（0.5%-5%；中位数为2%）。8例患者在平均10个月（3-18个月）后接受临床随访。随访时温哥华瘢痕量表平均评分为1.5分（范围0-5分）。创面上皮化平均时间为12.5天。我们的数据表明，与其他任何方法相比，酶促和仔细的手术清创以及使用喷雾技术连续应用CMEA悬浮液可产生优异的美容效果。
