Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
J Mol Biol. 2023 Jun 1;435(11):167860. doi: 10.1016/j.jmb.2022.167860. Epub 2023 Jun 16.
Viruses infect all kingdoms of life; their genomes vary from DNA to RNA and in size from 2kB to 1 MB or more. Viruses frequently employ disordered proteins, that is, protein products of virus genes that do not themselves fold into independent three-dimensional structures, but rather, constitute a versatile molecular toolkit to accomplish a range of functions necessary for viral infection, assembly, and proliferation. Interestingly, disordered proteins have been discovered in almost all viruses so far studied, whether the viral genome consists of DNA or RNA, and whatever the configuration of the viral capsid or other outer covering. In this review, I present a wide-ranging set of stories illustrating the range of functions of IDPs in viruses. The field is rapidly expanding, and I have not tried to include everything. What is included is meant to be a survey of the variety of tasks that viruses accomplish using disordered proteins.
病毒感染所有生命领域；它们的基因组从 DNA 到 RNA 不等，大小从 2kb 到 1MB 或更大。病毒经常使用无序蛋白，即病毒基因的蛋白质产物本身不会折叠成独立的三维结构，而是构成了一种通用的分子工具包，用于完成一系列对病毒感染、组装和增殖必不可少的功能。有趣的是，迄今为止研究过的几乎所有病毒都发现了无序蛋白，无论病毒基因组是由 DNA 还是 RNA 组成，以及病毒衣壳或其他外壳的结构如何。在这篇综述中，我展示了一系列广泛的故事，说明了 IDP 在病毒中的一系列功能。该领域正在迅速发展，我并没有试图囊括所有内容。本文所包含的内容旨在概述病毒使用无序蛋白完成的各种任务。
