Liljequist S, Andén N E, Engel J, Henning M
J Neural Transm. 1978;43(1):11-7. doi: 10.1007/BF02029015.
The effects of the central noradrenaline receptor stimulating agent clonidine on blood pressure, heart rate, and flexor reflex activity were studied in intact rats and in rats chronically treated with ethanol. The clonidine-induced changes were similar in ethanol-treated animals and in animals never subjected to ethanol. The results suggest that the sensitivity of central noradrenaline receptors involved in the mediation of the circulatory changes and of the flexor reflex activity after clonidine is not altered by chronic administration of ethanol.
在完整大鼠和长期用乙醇处理的大鼠中，研究了中枢去甲肾上腺素受体激动剂可乐定对血压、心率和屈肌反射活动的影响。可乐定引起的变化在乙醇处理的动物和从未接触过乙醇的动物中相似。结果表明，长期给予乙醇不会改变可乐定后参与介导循环变化和屈肌反射活动的中枢去甲肾上腺素受体的敏感性。
