与乙醇依赖和戒断相关的小鼠大脑中单胺浓度的变化。
Changes in monoamine concentrations in mouse brain associated with ethanol dependence and withdrawal.
作者信息
Griffiths P J, Littleton J M, Ortiz A
出版信息
Br J Pharmacol. 1974 Apr;50(4):489-98. doi: 10.1111/j.1476-5381.1974.tb08582.x.
Abstract
1 Chronic administration of ethanol to mice by inhalation induced tolerance to ethanol and produced an increase in the concentration of brain monoamines.2 Withdrawal of ethanol from dependent mice caused behavioural changes associated with a further transient rise in brain monoamine concentrations which then declined to control levels.3 Inhibition of the withdrawal syndrome by the administration of ethanol postponed the changes in monoamines associated with withdrawal.4 Administration of inhibitors of catecholamine synthesis before withdrawal of ethanol modified the withdrawal syndrome.
摘要
通过吸入方式对小鼠长期给予乙醇会诱导其对乙醇产生耐受性，并导致脑单胺浓度升高。
使依赖乙醇的小鼠戒断乙醇会引起行为变化，同时脑单胺浓度进一步短暂升高，随后降至对照水平。
给予乙醇可抑制戒断综合征，从而推迟与戒断相关的单胺变化。
在乙醇戒断前给予儿茶酚胺合成抑制剂可改变戒断综合征。
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