Laffer U, Jäggi P, Harder F, Metzger U, Egeli R, Weber W, Barras J P, Schweizer W, Müller W, Martinoli S
Helv Chir Acta. 1989 Dec;56(4):461-4.
More recently a number of retrospective analyses in rather ill defined patient populations demonstrated an association between perioperative blood transfusion and recurrence after curative resection of colorectal cancer. In the randomized trial (SAKK 40/81) (adjuvant cytotoxic intraportal infusion versus no further treatment) we evaluated the transfusion status in a well defined, prospectively documented and controlled patient population. Of 457 patients, 353 (77.2%) received either pre-, intra- or postoperatively blood transfusions. After a median follow-up of 4 years, the transfused patients developed significantly more recurrences (38.2%) than patients without blood transfusions (23.1%), the death-rate being 33.7% versus 23.0%, respectively. Patients without transfusion but treated with adjuvant intraportal chemotherapy are strikingly doing better (10.5% recurrences) than patients with perioperative blood transfusion not having an adjuvant treatment (44.5% recurrences).
最近，在定义相当不明确的患者群体中进行的一些回顾性分析表明，围手术期输血与结直肠癌根治性切除术后复发之间存在关联。在一项随机试验（SAKK 40/81）（辅助性细胞毒性门静脉内输注与不进行进一步治疗）中，我们在一个定义明确、前瞻性记录且得到控制的患者群体中评估了输血状况。在457例患者中，353例（77.2%）在术前、术中和术后接受了输血。经过4年的中位随访，输血患者的复发率（38.2%）明显高于未输血患者（23.1%），死亡率分别为33.7%和23.0%。未输血但接受辅助性门静脉内化疗的患者（复发率10.5%）明显比接受围手术期输血但未接受辅助治疗的患者（复发率44.5%）情况更好。
