Singh Surya
Department of Integrative Biology, University of California, Berkeley, California 94720, USA.
J Nanosci Nanotechnol. 2010 Dec;10(12):7906-18. doi: 10.1166/jnn.2010.3617.
Significant progress has been made in nanoscale drugs and delivery systems employing diverse chemical formulations to facilitate the rate of drug delivery and release from the human body. The biocompatible nanomaterials have been used in biological markers, contrast agents for biological imaging, healthcare products, pharmaceuticals, drug-delivery systems as well as in detection, diagnosis and treatment of various types of diseases. Nanomedicines offer delivery of potential drugs to human organs which were previously beyond reach of microscale drugs due to specific biological barriers. The nanoscale systems work as nanocarriers for the delivery of drugs. The nanocarriers are made of biocompatible and biodegradable materials such as synthetic proteins, peptides, lipids, polysaccharides, biodegradable polymers and fibers. This review article reports the recent developments in the field of nanomedicine covering biodegradable polymers, nanoparticles, cyclodextrin, dendrimeres, liposomes and lipid-based nanocarriers, nanofibers, nanowires and carbon nanotubes and their chemical functionalization for distribution to different organs, their solubility, surface, chemical and biological properties, stability and release systems. The toxicity and safety of nanomaterials on human health is also briefly discussed.
在利用多种化学配方的纳米级药物和递送系统方面已取得重大进展,以促进药物递送速率以及从人体释放。生物相容性纳米材料已用于生物标志物、生物成像造影剂、保健产品、药品、药物递送系统,以及各种疾病的检测、诊断和治疗。纳米药物能够将潜在药物递送至人体器官,而由于特定的生物屏障,这些器官以前是微米级药物无法到达的。纳米级系统作为药物递送的纳米载体。纳米载体由生物相容性和可生物降解材料制成,如合成蛋白质、肽、脂质、多糖、可生物降解聚合物和纤维。这篇综述文章报道了纳米医学领域的最新进展,涵盖可生物降解聚合物、纳米颗粒、环糊精、树枝状大分子、脂质体和基于脂质的纳米载体、纳米纤维、纳米线和碳纳米管,以及它们为分布到不同器官而进行的化学功能化、它们的溶解性、表面、化学和生物学性质、稳定性和释放系统。还简要讨论了纳米材料对人类健康的毒性和安全性。