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纳米药物在疟疾治疗方面的进展。

Advances in nanomedicines for malaria treatment.

机构信息

Food Nanotechnology Laboratory, Department of Food Science and Technology, Sejong University, Seoul-143-747, Republic of Korea.

出版信息

Adv Colloid Interface Sci. 2013 Dec;201-202:1-17. doi: 10.1016/j.cis.2013.10.014. Epub 2013 Oct 19.

Abstract

Malaria is an infectious disease that mainly affects children and pregnant women from tropical countries. The mortality rate of people infected with malaria per year is enormous and became a public health concern. The main factor that has contributed to the success of malaria proliferation is the increased number of drug resistant parasites. To counteract this trend, research has been done in nanotechnology and nanomedicine, for the development of new biocompatible systems capable of incorporating drugs, lowering the resistance progress, contributing for diagnosis, control and treatment of malaria by target delivery. In this review, we discussed the main problems associated with the spread of malaria and the most recent developments in nanomedicine for anti-malarial drug delivery.

摘要

疟疾是一种传染病,主要影响来自热带国家的儿童和孕妇。每年感染疟疾的人的死亡率非常高,已成为公共卫生关注的问题。导致疟疾传播成功的主要因素是抗药性寄生虫数量的增加。为了应对这一趋势,纳米技术和纳米医学的研究已经在进行,以开发新的生物相容性系统,能够结合药物,降低耐药性进展,通过靶向递送来促进疟疾的诊断、控制和治疗。在这篇综述中,我们讨论了与疟疾传播相关的主要问题以及纳米医学在抗疟药物传递方面的最新进展。

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