Etchepareborde S, Heimann M, Cohen-Solal A, Hamaide A
Department of Clinical Sciences, School of Veterinary Medicine, University of Liège, Boulevard de Colonster 20, 4000 Liege, Belgium.
J Small Anim Pract. 2010 Dec;51(12):649-53. doi: 10.1111/j.1748-5827.2010.00998.x.
A German shepherd dog was diagnosed with sclerosing encapsulating peritonitis after an episode of peritonitis caused by a free intra-abdominal foreign body (stick). The foreign body had initially been treated by surgical removal and abdominal lavage. Postoperatively, peritoneal effusion persisted despite the use of methylprednisolone for 1 month and a second surgical exploration and abdominal lavage. After a third surgery at our institution (to breakdown abdominal adhesions) followed by open abdominal drainage, treatment with tamoxifen orally was initiated and within 2 weeks the dog's condition improved dramatically. Two months later, no fluid was present in the abdomen. The only apparent adverse reaction to tamoxifen therapy was swelling of the vulva. In humans, sclerosing encapsulating peritonitis is a known life-threatening complication following peritoneal dialysis. In veterinary medicine, most animals with sclerosing encapsulating peritonitis die because of chronic weight loss, peritoneal effusion and progression of concurrent disease. This dog's condition was unresponsive to methylprednisolone alone but was successfully treated with aggressive surgery including enterolysis and open abdominal lavage and the addition of tamoxifen.
一只德国牧羊犬在因腹腔内游离异物（木棍）引发腹膜炎后，被诊断为硬化性包裹性腹膜炎。该异物最初通过手术取出和腹腔灌洗进行治疗。术后，尽管使用甲基强的松龙治疗1个月，并进行了第二次手术探查和腹腔灌洗，但腹腔积液仍持续存在。在我们机构进行第三次手术（分解腹腔粘连）并进行开放式腹腔引流后，开始口服他莫昔芬治疗，两周内这只狗的病情显著改善。两个月后，腹腔内没有积液。他莫昔芬治疗唯一明显的不良反应是阴囊肿胀。在人类中，硬化性包裹性腹膜炎是腹膜透析后一种已知的危及生命的并发症。在兽医学中，大多数患有硬化性包裹性腹膜炎的动物因慢性体重减轻、腹腔积液和并发疾病的进展而死亡。这只狗的病情对单独使用甲基强的松龙无反应，但通过包括肠粘连松解术和开放式腹腔灌洗在内的积极手术以及添加他莫昔芬成功治愈。
