Kim Chaerin, Kim Sanggu, Park Jinhyeong, Lee Dohee, Chae Yeon, Yun Taesik, Chang Dongwoo, Kang Byeong-Teck, Lee Sungin, Kim Soochong, Kim Hakhyun
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
Front Vet Sci. 2024 Jul 31;11:1406223. doi: 10.3389/fvets.2024.1406223. eCollection 2024.
A 9-year-old, neutered male, domestic short-haired cat was referred for recurrent ascites of unknown etiology over a week. Physical examination revealed abdominal distension and ultrasonography revealed a large volume of ascites throughout the abdominal cavity; this was interpreted as modified transudate. The mesentery and abdominal fat were hyperechoic and edematous. Fat tissue was assessed using fine-needle aspiration cytology, and adipocytes, fat-phagocytizing macrophages, and neutrophils were identified. Computed tomography revealed a pancreatic mass connected to the left pancreatic leg. Exploratory laparoscopy confirmed nodular masses and organ adhesions, leading to a tentative diagnosis of sclerosing encapsulating peritonitis. The cat was administered prednisolone, vitamin E, and tamoxifen but died 22 days after the initial therapy. Necropsy revealed a multi-lobulated pancreatic tumor (10 × 10 cm) tightly attached to the stomach and intestine, with a large amount of ascites. The peritoneum, stomach, intestine, and mesentery were covered with numerous disseminated nodules of various sizes (1-5 mm diameter). Microscopically, the tumor consisted of extensive adipose tissue, locally extensive inflammatory infiltrates, fibrous connective tissue, and small invasive proliferative glands. Well-defined small irregular glands composed of single-layered epithelial cells that appear to be of ductal origin were surrounded by an abundant desmoplastic stroma. Neoplastic nodules were widespread in the liver, stomach, peritoneum, mesentery, mesenteric lymph nodes, lungs, and urinary bladder. Immunohistochemistry revealed that the neoplastic glands were positive for pan-cytokeratin, confirming the pancreatic epithelial origin of the tumor. This is the first report of sclerosing encapsulating peritonitis accompanied by aggressive pancreatic adenocarcinoma of presumed ductal origin and extensive metastasis in a cat.
一只9岁已绝育的雄性家养短毛猫因不明病因的反复腹水被转诊，病程超过一周。体格检查发现腹部膨隆，超声检查显示整个腹腔有大量腹水，腹水被解释为改良漏出液。肠系膜和腹部脂肪回声增强且水肿。通过细针穿刺细胞学检查评估脂肪组织，发现了脂肪细胞、吞噬脂肪的巨噬细胞和中性粒细胞。计算机断层扫描显示胰腺有一个肿块与左胰腿相连。 exploratory laparoscopy确认有结节状肿块和器官粘连，初步诊断为硬化性包裹性腹膜炎。给这只猫使用了泼尼松龙、维生素E和他莫昔芬，但在初始治疗后22天死亡。尸检发现一个多叶状胰腺肿瘤（10×10厘米）紧密附着于胃和肠道，伴有大量腹水。腹膜、胃、肠道和肠系膜布满了许多大小不一（直径1 - 5毫米）的散在结节。显微镜下，肿瘤由广泛的脂肪组织、局部广泛的炎症浸润、纤维结缔组织以及小的浸润性增殖腺体组成。由单层上皮细胞组成的界限清晰的小不规则腺体，看似起源于导管，被丰富的促纤维增生性基质所包围。肿瘤结节广泛分布于肝脏、胃、腹膜、肠系膜、肠系膜淋巴结、肺和膀胱。免疫组织化学显示肿瘤腺体对泛细胞角蛋白呈阳性，证实了肿瘤的胰腺上皮起源。这是首例关于猫硬化性包裹性腹膜炎伴推测起源于导管的侵袭性胰腺腺癌及广泛转移的报道。 （注：原文中“Exploratory laparoscopy”未准确翻译，推测可能是“探查性腹腔镜检查” ）
