Immunology Division, School of Dentistry, Department of Human Dynamics, University of Chieti, Chieti, Italy.
J Biol Regul Homeost Agents. 2010 Oct-Dec;24(4):385-90.
Cytokines are important proteins that modulate immunity and inflammation. Vitamins are also involved in immunity and inflammation. They are found to restore the ability of some cells to produce certain cytokines. Vitamin deficiency appears to affect the mechanism of immune cells, though the impact of reduced cytokine response in vitamin malnutrition is not clear. Vitamin D is involved in many medical conditions, such as infections and inflammation, and mediates innate immunity. Deficiency of vitamin D increases the risk of infectious and inflammatory diseases. In addition, this vitamin modulates Treg function and IL-10 production which is important for therapeutic treatment. Vitamin A increases inflammatory response and is involved in tissue damage; moreover, vitamin A is a key modulator of TGFbeta which can suppress several cytokines. Vitamin E, an anti-ageing compound, is associated with a defect of naive T cells and may inhibit some inflammatory compounds such as prostaglandin generation.
细胞因子是调节免疫和炎症的重要蛋白质。维生素也参与免疫和炎症。它们被发现可以恢复某些细胞产生某些细胞因子的能力。维生素缺乏似乎会影响免疫细胞的机制，尽管维生素营养不良中细胞因子反应减少的影响尚不清楚。维生素 D 参与许多医学病症，如感染和炎症，并介导先天免疫。维生素 D 缺乏会增加感染和炎症性疾病的风险。此外，这种维生素调节 Treg 功能和 IL-10 的产生，这对于治疗很重要。维生素 A 会增加炎症反应并参与组织损伤；此外，维生素 A 是 TGFbeta 的关键调节剂，可抑制几种细胞因子。维生素 E 是一种抗衰老化合物，与幼稚 T 细胞缺陷有关，可能抑制一些炎症化合物的产生，如前列腺素的生成。
