Institute of Laboratory Medicine, Faculty of Medicine, University of Pécs, Pécs, Hungary.
J Crohns Colitis. 2010 Dec;4(6):649-53. doi: 10.1016/j.crohns.2010.07.010.
One of the major symptoms of chronic inflammatory bowel diseases is anemia. The two most common diseases are Crohn's disease and ulcerative colitis. Anemia may develop due to intestinal bleeding, iron absorption disturbances, or high levels of inflammatory cytokines. It is not clear whether or not hepcidin, the only known hormone regulating cellular iron uptake in mammals is involved. The transcription of hepcidin is controlled by the iron status of the body, hypoxia, and/or inflammation. This study was meant to find relationship between serum prohepcidin levels and clinical parameters of iron homeostasis or inflammatory state in patients suffering from Crohn's disease or ulcerative colitis.
Serum prohepcidin levels were measured with ELISA in 72 patients diagnosed with ulcerative colitis and 30 patients suffering from Crohn's disease.
In both groups serum iron levels were lower, while levels of C-reactive protein were higher than in the healthy controls. Serum prohepcidin levels showed no significant differences compared to those in the control group. In the affected patients only weak correlations were observed between prohepcidin levels and diagnostic parameters: in Crohn's disease prohepcidin levels correlated positively with transferrin levels, total iron-binding capacity, transferrin saturation, activity index, and serum albumin levels, while in ulcerative coltitis prohepcidin levels were related to transferrin levels and transferrin saturation.
It seems obvious that serum prohepcidin level determination in itself is not a satisfactory diagnostic or prognostic measure in anemia of chronic inflammatory bowel diseases.
慢性炎症性肠病的主要症状之一是贫血。最常见的两种疾病是克罗恩病和溃疡性结肠炎。贫血可能是由于肠道出血、铁吸收障碍或炎症细胞因子水平升高引起的。目前尚不清楚调节哺乳动物细胞铁摄取的唯一已知激素——铁调素是否参与其中。铁调素的转录受机体铁状态、缺氧和/或炎症的控制。本研究旨在探讨克罗恩病和溃疡性结肠炎患者血清铁调素前肽水平与铁稳态或炎症状态临床参数之间的关系。
采用 ELISA 法检测 72 例溃疡性结肠炎患者和 30 例克罗恩病患者血清铁调素前肽水平。
两组患者血清铁水平均降低，C 反应蛋白水平均高于对照组。与对照组相比，两组患者血清铁调素前肽水平无显著差异。在受影响的患者中，铁调素前肽水平仅与诊断参数之间存在微弱相关性：在克罗恩病中，铁调素前肽水平与转铁蛋白水平、总铁结合能力、转铁蛋白饱和度、活动指数和血清白蛋白水平呈正相关，而在溃疡性结肠炎中，铁调素前肽水平与转铁蛋白水平和转铁蛋白饱和度相关。
似乎很明显，在慢性炎症性肠病贫血中，血清铁调素前肽水平的测定本身并不是一种令人满意的诊断或预后指标。
