Paköz Zehra Betül, Çekiç Cem, Arabul Mahmut, Sarıtaş Yüksel Elif, İpek Serkan, Vatansever Sezgin, Ünsal Belkıs
Department of Gastroenterology, Izmir Katip Çelebi University, İzmir Atatürk Eğitim ve Araştırma Hastanesi, Karabağlar, 35160 İzmir, Turkey.
Gastroenterol Res Pract. 2015;2015:810942. doi: 10.1155/2015/810942. Epub 2015 Jan 1.
Aim. While there are many well-defined serological markers for inflammatory bowel disease (IBD), there is limited evidence that they positively affect clinical outcomes. This study aimed to evaluate the correlation between hepcidin serum levels and disease activity in IBD. Materials and Methods. Eighty-five consecutive IBD patients were enrolled in the study. Hepcidin serum levels were assessed using an enzyme-linked immunosorbent assay (ELISA) and were compared with disease activity as well as the interleukin-6 (IL-6) and C-reactive protein (CRP) levels. Results. The mean hepcidin serum levels in Crohn's disease (CD) patients in remission and in the active phase were 3837 ± 1436 and 3752 ± 1274 pg/mL, respectively (P = 0.613). The mean hepcidin serum levels in ulcerative colitis (UC) patients in remission and in the active phase were 4285 ± 8623 and 3727 ± 1176 pg/mL, respectively (P = 0.241). Correlation analysis between inflammatory markers and hepcidin serum levels indicated that there was no correlation between hepcidin levels and IL-6 (P = 0.582) or CRP (P = 0.783). Conclusion. As an acute-phase protein, hepcidin seems to have a lower efficacy than other parameters in the detection of activation in IBD.
目的。虽然有许多针对炎症性肠病（IBD）的明确血清学标志物，但证据表明它们对临床结局的积极影响有限。本研究旨在评估IBD患者血清中铁调素水平与疾病活动度之间的相关性。材料与方法。连续85例IBD患者纳入本研究。采用酶联免疫吸附测定（ELISA）评估血清铁调素水平，并与疾病活动度以及白细胞介素-6（IL-6）和C反应蛋白（CRP）水平进行比较。结果。克罗恩病（CD）缓解期和活动期患者的血清铁调素平均水平分别为3837±1436和3752±1274 pg/mL（P = 0.613）。溃疡性结肠炎（UC）缓解期和活动期患者的血清铁调素平均水平分别为4285±8623和3727±1176 pg/mL（P = 0.241）。炎症标志物与血清铁调素水平的相关性分析表明，铁调素水平与IL-6（P = 0.582）或CRP（P = 0.783）之间无相关性。结论。作为一种急性期蛋白，铁调素在检测IBD激活方面似乎比其他参数的效能更低。
