Department of Gastroenterology, University Hospital Heraklion, Crete, Greece.
Eur J Gastroenterol Hepatol. 2011 Mar;23(3):262-8. doi: 10.1097/MEG.0b013e328343b885.
Anemia is an important complication of inflammatory bowel disease (IBD). Recent data suggest that hepcidin is a major mediator of anemia with a central role in iron homeostasis and metabolism. The aim of this study was to evaluate the serum levels of hepcidin and its prohormone, prohepcidin, in patients with IBD in comparison with healthy controls.
One hundred patients with IBD [49 ulcerative colitis (UC), 51 Crohn's disease (CD)] and 102 healthy controls were enrolled. Serum hepcidin and prohepcidin levels were measured by commercially available enzyme-linked immunosorbent assays kits. Their relationship with clinical and laboratory parameters of UC and CD was assessed.
Median hepcidin levels were significantly higher in both patients with UC and patients with CD compared with healthy controls (P<0.0001). Median prohepcidin levels were significantly lower in patients with IBD compared with healthy controls (P = 0.03). In the univariate analysis, serum hepcidin was significantly negatively correlated (r = -0.36, P = 0.0003), whereas serum prohepcidin was positively correlated (r = 0.65, P<0.0001) with the hemoglobin levels. Significant correlations of both hepcidin (r = 0.34, P = 0.0007) and prohepcidin (r = -0.21, P = 0.04) with ferritin levels were found in patients with IBD. Serum hepcidin was also correlated with disease activity (for UC, r = 0.36, P = 0.009) and C-reactive protein (r = 0.29, P = 0.004). After multivariate analysis serum hepcidin levels remained significantly correlated with ferritin (P = 0.0008) and disease activity (for UC, P = 0.004).
Serum hepcidin and prohepcidin levels are significantly altered in patients with IBD compared with healthy controls. This finding suggests a substantial role of these two hormones in the development of anemia in IBD.
贫血是炎症性肠病（IBD）的重要并发症。最近的数据表明，铁调素是贫血的主要介质，在铁稳态和代谢中起着核心作用。本研究旨在评估 IBD 患者与健康对照者血清铁调素及其前体，即前铁调素的水平。
纳入 100 例 IBD 患者（49 例溃疡性结肠炎，51 例克罗恩病）和 102 例健康对照者。采用商业酶联免疫吸附试剂盒检测血清铁调素和前铁调素水平。评估其与 UC 和 CD 临床和实验室参数的关系。
UC 患者和 CD 患者的中位铁调素水平明显高于健康对照组（P<0.0001）。IBD 患者的中位前铁调素水平明显低于健康对照组（P=0.03）。在单变量分析中，血清铁调素与血红蛋白水平呈显著负相关（r=-0.36，P=0.0003），而血清前铁调素与血红蛋白水平呈显著正相关（r=0.65，P<0.0001）。在 IBD 患者中，铁调素（r=0.34，P=0.0007）和前铁调素（r=-0.21，P=0.04）与铁蛋白水平均有显著相关性。血清铁调素与疾病活动度（UC 患者，r=0.36，P=0.009）和 C 反应蛋白（r=0.29，P=0.004）也相关。多变量分析后，血清铁调素水平仍与铁蛋白（P=0.0008）和疾病活动度（UC 患者，P=0.004）显著相关。
与健康对照者相比，IBD 患者血清铁调素和前铁调素水平明显改变。这一发现表明这两种激素在 IBD 贫血的发生中起着重要作用。
