急性脊髓损伤的医学治疗。

Medical treatment of acute spinal cord injuries.

作者信息

Ceylan S, Kalelioğlu M, Aktürk G, Aktürk F, Ceylan S

机构信息

Department of Neurosurgery, Faculty of Medicine, Trabzon, Turkey.

出版信息

Res Exp Med (Berl). 1990;190(2):111-9. doi: 10.1007/pl00020013.

DOI:10.1007/pl00020013

PMID:2112263

Abstract

The injury was performed with 600 g-cm/weight on the spinal cord of 40 cats with T8-9 laminectomy in this study. Ten cats were given 10 mg/kg naloxone i.v. 1 h after injury. Ten cats were given 2 mg/kg thyrotropin-releasing hormone (TRH) i.v. 1 h after injury followed by 1 mg/kg per hour for 4 h. Intravenous lidocaine was begun 30 min after injury in ten cats, administered as 1.5 mg/kg over the initial 5 min, 3 mg/kg over the next 30 min and 1 mg/kg every 30 min for 4 h. The remaining ten cats were given only saline (control group). TRH-treated cats showed significantly better histopathological scores than either naloxone- or lidocaine-treated animals (KW:13.65, P less than 0.50).

摘要

在本研究中，对40只接受T8 - 9椎板切除术的猫的脊髓施加600克 - 厘米/重量的损伤。10只猫在损伤后1小时静脉注射10毫克/千克纳洛酮。10只猫在损伤后1小时静脉注射2毫克/千克促甲状腺激素释放激素（TRH），随后4小时内每小时注射1毫克/千克。10只猫在损伤后30分钟开始静脉注射利多卡因，最初5分钟内以1.5毫克/千克给药，接下来30分钟内以3毫克/千克给药，然后4小时内每30分钟以1毫克/千克给药。其余10只猫仅给予生理盐水（对照组）。接受TRH治疗的猫的组织病理学评分明显优于接受纳洛酮或利多卡因治疗的动物（KW：13.65，P小于0.50）。