实验性脊髓损伤的组织病理学。促甲状腺激素释放激素、纳洛酮和地塞米松治疗的比较。

Histopathology of experimental spinal cord trauma. Comparison of treatment with TRH, naloxone, and dexamethasone.

作者信息

Akdemir H, Paşaoğlu A, Oztürk F, Selçuklu A, Koç K, Kurtsoy A

机构信息

Department of Neurosurgery, Erciyes University Medical School, Kayseri, Turkey.

出版信息

Res Exp Med (Berl). 1992;192(3):177-83. doi: 10.1007/BF02576273.

DOI:10.1007/BF02576273

PMID:1636062

Abstract

The results of treatment with thyrotropin-releasing hormone (TRH), naloxone and dexamethasone treatments albino rats with experimental spinal cord injury were compared. All the animals were made paraplegic by the application clip method of Rivlin and Tator. Treatment was administered i.p. as bolus injections in two doses, at 45 and 120 min after the injury. Animals were allocated randomly to four experimental groups: (1) TRH (0.6 mg per dose), (2) naloxone (0.8 mg per dose), (3) dexamethasone (0.6 mg per dose), and (4) control (saline). TRH-treated rats showed significantly better histopathological scores than either naloxone or dexamethasone-treated ones (Kruskal Wallis: 24.058 P less than 0.001).

摘要

比较了促甲状腺激素释放激素（TRH）、纳洛酮和地塞米松对实验性脊髓损伤的白化大鼠的治疗结果。所有动物均采用Rivlin和Tator的夹闭法造成截瘫。在损伤后45分钟和120分钟，通过腹腔注射大剂量药物进行治疗，分两剂给药。动物被随机分为四个实验组：（1）TRH（每剂0.6毫克），（2）纳洛酮（每剂0.8毫克），（3）地塞米松（每剂0.6毫克），以及（4）对照组（生理盐水）。TRH治疗的大鼠组织病理学评分明显优于纳洛酮或地塞米松治疗的大鼠（Kruskal Wallis检验：24.058，P<0.001）。