Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States.
Curr Opin Immunol. 2011 Feb;23(1):21-8. doi: 10.1016/j.coi.2010.11.004. Epub 2010 Nov 29.
During the first week after sexual exposure to HIV, HIV infection does not appear to trigger a strong innate immune response. Here we describe some recent studies that show that HIV may avoid triggering antiviral innate immune responses by not replicating efficiently in dendritic cells and by avoiding detection in infected CD4 T cells and macrophages by harnessing a host cytoplasmic DNase TREX1 to digest nonproductive HIV reverse transcripts.
在初次性接触到 HIV 的第一周内,HIV 感染似乎并没有引发强烈的先天免疫反应。在这里,我们描述了一些最近的研究,这些研究表明,HIV 可能通过以下几种方式避免触发抗病毒的先天免疫反应:在树突状细胞中不能有效复制,以及利用宿主细胞质 DNA 酶 TREX1 来消化非生产性的 HIV 逆转录产物,从而避免被感染的 CD4 T 细胞和巨噬细胞检测到。