Mussoni L, Poggi A, Donati M B, de Gaetano G
Haemostasis. 1977;6(4):260-5. doi: 10.1159/000214188.
Ditazole (4,5-diphenyl-2-bis-(2-hydroxyethyl)-aminoxazol) inhibits in vivo platelet aggregation induced in mice by intravenous injection of cells derived from an experimental tumor, the Lewis lung carcinoma. Such a protective effect of ditazole could not be observed when the number of circulating platelets dropped slowly following intramuscular implantation and spontaneous dissemination of the same cancer cells. These results support previous observations suggesting a different mechanism for the thrombocytopenia observed after intravenous and intramuscular injection of cancer cells. Tail transection bleeding time of normal mice is significantly prolonged by ditazole, a finding at variance with that reported in rats.
地他唑（4,5 - 二苯基 - 2 - 双 -（2 - 羟乙基）- 氨基恶唑）可抑制小鼠体内因静脉注射源自实验性肿瘤——Lewis肺癌的细胞所诱导的血小板聚集。当同样的癌细胞经肌肉植入并自发扩散后，循环血小板数量缓慢下降时，未观察到地他唑的这种保护作用。这些结果支持了之前的观察结果，即静脉注射和肌肉注射癌细胞后所观察到的血小板减少症存在不同机制。地他唑可显著延长正常小鼠的尾部切断出血时间，这一发现与大鼠的报道结果不同。
