Centro de Investigaciones sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.
Sex Transm Dis. 2011 Apr;38(4):275-8. doi: 10.1097/OLQ.0b013e3181feae89.
To determine the factors associated with high-risk human papillomavirus (HR-HPV) and its incidence in a cohort of female college students, with particular emphasis on the use of condoms.
A cohort was created during 2001 to 2005. The students signed informed consent, answered a questionnaire, and provided a vaginal scrape to detect HR-HPV. Incidences were estimated and risk factors were evaluated using Cox proportional risk model. The variable condom use was constructed based on the following 3 measurements: relative frequency throughout one's lifetime, use during the first sexual relationship, and use during the last sexual relationship.
A total of 237 women participated, providing 395.6 person-years of follow-up. An incidence of 15.9 HR-HPV infection per 100 person-years was estimated and the factors associated with HR-HPV infection were found to be self-reported sexually transmitted infections (RR = 2.7), use of emergency contraception pill (ECP) (RR = 2.0), and having 2 or more sexual partners (RR = 1.9). University students using the ECP demonstrated more risky sexual behavior than nonusers. Women with 2 or more sexual partners who reported inconsistent condom use had 3.8 times the rate of HR-HPV infection.
The incidence for HR-HPV in this cohort of Mexican female college students is comparable to that found in the United States and Canada. The results suggest that the consistent use of condoms is a protective factor against HR-HPV, especially for women with multiple sexual partners and/or those who use the ECP.
确定与高危型人乳头瘤病毒（HR-HPV）相关的因素及其在女性大学生队列中的发生率，特别强调使用避孕套。
在 2001 年至 2005 年期间创建了一个队列。学生签署知情同意书，回答问卷，并提供阴道刮片以检测 HR-HPV。使用 Cox 比例风险模型估计发生率并评估危险因素。避孕套使用变量是基于以下 3 项测量构建的：一生中的相对频率、首次性关系期间的使用以及最近一次性关系期间的使用。
共有 237 名女性参与，提供了 395.6 人年的随访。估计每 100 人年有 15.9 例 HR-HPV 感染，与 HR-HPV 感染相关的因素是自我报告的性传播感染（RR=2.7）、使用紧急避孕药（RR=2.0）和有 2 个或更多性伴侣（RR=1.9）。使用紧急避孕药的大学生表现出更危险的性行为。报告避孕套使用不一致的有 2 个或更多性伴侣的女性，HR-HPV 感染率是无使用的 3.8 倍。
在本队列中，墨西哥女大学生的 HR-HPV 发生率与美国和加拿大相似。结果表明，避孕套的持续使用是 HR-HPV 的保护因素，特别是对于有多个性伴侣和/或使用紧急避孕药的女性。
