Sirvent J J, Bernat R, Navarro M A, Rodriguez Tolra J, Guspi R, Bosch R
Pathology Department, Tortosa Hospital Verge de la Cinta, Tarragona, Spain.
Eur Urol. 1990;17(3):257-61. doi: 10.1159/000464051.
In a group of 31 patients with idiopathic varicocele (IV), testicular biopsy showed a decreased tubular diameter, hyperplasia in the number of Leydig's cells (LC; many with cytoplasmic vacuolization and atrophy) and a decrease in the number of positive LC in testicular tissue sections stained with the testosterone peroxidase-antiperoxidase method. Similar values were seen for the testis with IV and for the contralateral testis. All of this, in addition to the lack of significant differences in the volume of cytoplasmic organelles in the LC, leads us to think that both testes are equally involved. Estradiol levels were significantly increased and testosterone, FSH and LH were normal in peripheral blood (compensated LC dysfunction).
在一组31例特发性精索静脉曲张（IV）患者中，睾丸活检显示管径减小，Leydig细胞（LC）数量增生（许多细胞有细胞质空泡化和萎缩），并且在用睾酮过氧化物酶-抗过氧化物酶方法染色的睾丸组织切片中，阳性LC数量减少。IV侧睾丸和对侧睾丸的情况相似。所有这些，再加上LC中细胞质细胞器体积没有显著差异，使我们认为双侧睾丸均同等程度受累。外周血中雌二醇水平显著升高，而睾酮、促卵泡激素（FSH）和促黄体生成素（LH）正常（代偿性LC功能障碍）。
