Ibrahim Z H, Matson P L, Buck P, Critchlow J D, Newman M C, Horne G, Hughes S, Lieberman B A
Regional IVF Unit, St. Mary's Hospital, Whitworth Park, Manchester, UK.
Hum Reprod. 1990 Apr;5(3):258-62. doi: 10.1093/oxfordjournals.humrep.a137084.
Daily s.c. injections of buserelin were commenced in the mid-luteal phase of the preceding cycle in 118 women undergoing in-vitro fertilization (IVF) and embryo transfer. Ovarian and pituitary suppression was said to have been adequately achieved when serum oestradiol was less than 50 pg/ml, serum LH less than 2.0 IU/l, no ovarian cysts greater than or equal to 10 mm diameter were present and menstruation had occurred. Nine groups of women were retrospectively identified after the administration of buserelin for 12 days according to whether pituitary and ovarian suppression had been achieved or not, and the reason for extended buserelin treatment prior to ovarian stimulation. Upon adequate suppression, patients were grouped in terms of the duration of exposure to buserelin, and ovarian stimulation was then started by daily injections of human menopausal gonadotrophin. There appeared to be no differences in the ovarian response for women down-regulated by day 12, 19 or greater than or equal to 26 days; those women requiring extended buserelin treatment did equally well compared to those women down-regulating quickly, in terms of number of oocytes recovered and fertilization rate. Clinical pregnancy rates per embryo transfer were 27/68(40%), 8/33(26%) and 4/17(24%) for those women down-regulated by days 12, 19 or greater than or equal to 26 respectively, and were not significantly different.
对118名接受体外受精（IVF）和胚胎移植的女性，在前一周期的黄体中期开始每日皮下注射布舍瑞林。当血清雌二醇低于50 pg/ml、血清促黄体生成素低于2.0 IU/l、不存在直径大于或等于10 mm的卵巢囊肿且已发生月经时，据说已充分实现了卵巢和垂体抑制。根据是否实现垂体和卵巢抑制以及在卵巢刺激前延长布舍瑞林治疗的原因，在给予布舍瑞林12天后对九组女性进行回顾性鉴定。在充分抑制后，根据布舍瑞林暴露时间对患者进行分组，然后通过每日注射人绝经期促性腺激素开始卵巢刺激。在第12天、第19天或大于或等于26天被下调的女性中，卵巢反应似乎没有差异；就回收的卵母细胞数量和受精率而言，那些需要延长布舍瑞林治疗的女性与那些快速下调的女性表现同样良好。对于分别在第12天、第19天或大于或等于26天被下调的女性，每次胚胎移植的临床妊娠率分别为27/68（40%）、8/33（26%）和4/17（24%），且无显著差异。
