Session D R, Saad A H, Salmansohn D D, Kelly A C
Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York, USA.
J Assist Reprod Genet. 1995 May;12(5):301-4. doi: 10.1007/BF02213708.
Previous reports have suggested that the ovarian response to leuprolide acetate is predictive of in vitro fertilization pregnancy rates. This study evaluated the outcome of in vitro fertilization cycles complicated by elevated estradiol levels during leuprolide acetate down regulation and the outcome of subsequent cycles in the same patients.
Two hundred fifty-two in vitro fertilization cycles were initiated utilizing leuprolide acetate down regulation beginning on cycle day 1.
Seventy-four of these cycles had an elevated estradiol level at the time of the baseline scan (28%). This group of patients had a higher maternal age, a higher cycle cancellation rate (27.5 vs 16.3%), and a high rate of recurrence on subsequent cycles (63%).
The pregnancy rate per retrieval was equivalent in the two groups. This suggests that patients with advanced maternal age or a history of failure to suppress in a previous cycle may benefit from alternate regimens of superovulation.
既往报告提示，卵巢对醋酸亮丙瑞林的反应可预测体外受精的妊娠率。本研究评估了在醋酸亮丙瑞林降调节期间雌二醇水平升高的体外受精周期的结局以及同一患者后续周期的结局。
从周期第1天开始使用醋酸亮丙瑞林降调节启动了252个体外受精周期。
其中74个周期在基线扫描时雌二醇水平升高（28%）。该组患者的产妇年龄较大，周期取消率较高（27.5%对16.3%），且后续周期的复发率较高（63%）。
两组每次取卵的妊娠率相当。这表明产妇年龄较大或既往周期抑制失败的患者可能从替代的超排卵方案中获益。
