de la Rosa-Prieto Carlos, Saiz-Sánchez Daniel, Úbeda-Bañón Isabel, Mohedano-Moriano Alicia, Martínez-Marcos Alino
Neuroplasticity and Neurodegeneration Laboratory, Departamento de Ciencias Médicas, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Ciudad Real, Spain.
Neuroreport. 2011 Jan 5;22(1):28-32. doi: 10.1097/WNR.0b013e328341fb66.
The olfactory and vomeronasal epithelia detect chemical stimuli in most tetrapods. Both epithelia undergo neural replacement during adulthood. In the central regions of vomeronasal epithelium, similar rates of neurogenesis and apoptosis evidence balanced replacement mechanisms. In the margins, the rate of neurogenesis is several times higher as compared with the rate of apoptosis suggesting net addition of neural receptor cells during adulthood. Herein, the fate of these marginal neuroblasts has been investigated in adult mice. Newly born and mature receptor neurons have been labeled. In the margins, more than 60% of new-born cells send axons to the accessory olfactory bulb. These results evidence that new neural elements from the vomeronasal epithelium are added to the accessory olfactory bulb preexisting circuitry.
在大多数四足动物中，嗅觉上皮和犁鼻器上皮可检测化学刺激。成年期这两种上皮都会进行神经更替。在犁鼻器上皮的中央区域，神经发生和细胞凋亡的速率相似，表明存在平衡的更替机制。在边缘区域，神经发生的速率比细胞凋亡的速率高几倍，这表明成年期神经受体细胞有净增加。在此，研究了成年小鼠中这些边缘神经母细胞的命运。新生和成熟的受体神经元已被标记。在边缘区域，超过60%的新生细胞将轴突发送到副嗅球。这些结果表明，来自犁鼻器上皮的新神经元件被添加到副嗅球的既有神经回路中。
