Kadota T, Mimura K, Kanabe S, Ohsaki Y, Tamakuma S
First Surgical Department, National Defense Medical College, Saitama, Japan.
Surgery. 1990 Jun;107(6):655-60.
Proximal gastric vagotomy has been widely used as a surgical treatment for peptic ulcer disease. However, it is technically complex and time-consuming. Moreover, it may cause circulatory problems in the gastric mucosa. We have reported a new method of blood flow-preserving vagotomy with a carbon dioxide laser (CO2 laser vagotomy) developed in our laboratory. To assess its efficacy, we used cysteamine-induced ulcer and measured gastric mucosal blood flow in rats. The incidence of cysteamine-induced ulcer formation was reduced significantly in the group that underwent CO2 laser vagotomy compared with a group treated with proximal gastric vagotomy. Gastric mucosal blood flow was significantly better in the CO2 laser vagotomy group. Long-term follow-up of acid reduction was evaluated in dogs by the pentagastrin-stimulation test. Acid reduction in dogs was satisfactory during the 12 months of this study. CO2 laser vagotomy is a new, easy, time-saving, and circulatory-preserving technique for peptic ulcer disease.
近端胃迷走神经切断术已被广泛用作消化性溃疡疾病的外科治疗方法。然而，该手术技术复杂且耗时。此外，它可能会导致胃黏膜出现循环问题。我们报告了一种在我们实验室开发的新型保留血流的迷走神经切断术——二氧化碳激光迷走神经切断术（CO2激光迷走神经切断术）。为了评估其疗效，我们使用半胱胺诱导大鼠溃疡，并测量胃黏膜血流量。与接受近端胃迷走神经切断术治疗的组相比，接受CO2激光迷走神经切断术的组中半胱胺诱导溃疡形成的发生率显著降低。CO2激光迷走神经切断术组的胃黏膜血流量明显更好。通过五肽胃泌素刺激试验对犬进行了胃酸分泌减少的长期随访评估。在本研究的12个月期间，犬的胃酸分泌减少情况令人满意。CO2激光迷走神经切断术是一种用于消化性溃疡疾病的新型、简便、省时且能保留循环的技术。
