Qureshi M A, Darzi A, Leahy A L, Bouchier-Hayes D J
Department of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Republic of Ireland.
Surg Laparosc Endosc. 1998 Oct;8(5):356-9.
This study assessed a novel approach using defocused carbon dioxide (CO2) laser irradiation on the gastric mucosal surface to reduce gastric acid output. Ninety-six Sprague-Dawley rats were randomised to three groups: control, surgical highly selective vagotomy (surgical-HSV), and gastric mucosal irradiation (laser-M). Cysteamine-induced peptic ulceration was studied, including ulcer index (product of the total number of ulcers by the sum of the ulcer length), at 4 weeks and 20 weeks. The mean ulcer index in the surgical-HSV group was significantly reduced compared with controls at 4 weeks and at 20 weeks. The mean ulcer index in the laser-M group was significantly reduced compared with controls at 4 weeks but not at 20 weeks. Histologic analysis did not reveal any mucosal changes in parietal cell mass at 4 weeks and at 20 weeks. The results show a transient antiulcer effect produced by the gastric mucosal irradiation seen at 4 weeks and abolished by 20 weeks. This data supports the feasibility of endoscopic management of peptic ulcer disease.
本研究评估了一种在胃黏膜表面使用散焦二氧化碳（CO₂）激光照射以减少胃酸分泌的新方法。96只Sprague-Dawley大鼠被随机分为三组：对照组、手术高选择性迷走神经切断术组（手术-HSV组）和胃黏膜照射组（激光-M组）。研究了半胱胺诱导的消化性溃疡，包括在4周和20周时的溃疡指数（溃疡总数与溃疡长度总和的乘积）。手术-HSV组在4周和20周时的平均溃疡指数与对照组相比显著降低。激光-M组在4周时的平均溃疡指数与对照组相比显著降低，但在20周时未降低。组织学分析在4周和20周时均未发现壁细胞数量有任何黏膜变化。结果显示，胃黏膜照射在4周时产生了短暂的抗溃疡作用，但在20周时消失。该数据支持了消化性溃疡疾病内镜治疗的可行性。
