Ruprich J, Piskac A
Institut hygieny a epidemiologie, Brno.
Vet Med (Praha). 1990 Feb;35(2):97-103.
A trial with the continual administration of feed contaminated with the Delor 103 preparation (polychlorinated biphenyls--PCB) at a rate of 75 mg per kg for chicks lasted four weeks. The concentrations of serum thyroxine and triiodothyronine were found to decrease, the concentrations of total calcium increased and at the Delor 103 doses of 150 mg per kg even the phosphorus concentration and the activity of alkaline phosphatase in the serum of chicks decreased. The addition of potassium iodide to feed (250 mg per kg) did not influence the clinical picture of Delor 103 intoxication. The results confirm a finding that in the course of PCB intoxication severe disorders of the thyroid gland take place and calcium metabolism is disturbed. This finding is important in view of evaluation of the intoxication of young, growing chicks.
一项针对雏鸡的试验,持续以每千克75毫克的剂量投喂被多氯联苯(PCB)制剂Delor 103污染的饲料,为期四周。结果发现,雏鸡血清甲状腺素和三碘甲状腺原氨酸浓度降低,总钙浓度升高,在Delor 103剂量为每千克150毫克时,雏鸡血清中的磷浓度和碱性磷酸酶活性甚至也降低了。在饲料中添加碘化钾(每千克250毫克)并未影响Delor 103中毒的临床表现。这些结果证实了一个发现,即在PCB中毒过程中,甲状腺会发生严重紊乱,钙代谢也会受到干扰。鉴于对幼小、正在生长的雏鸡中毒情况的评估,这一发现很重要。