Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
J Neuroimmunol. 2011 Mar;232(1-2):151-7. doi: 10.1016/j.jneuroim.2010.11.001. Epub 2010 Dec 3.
To determine the effect of the tolerogenic peptide hCDR1 on hippocampal neurogenesis, we treated SLE-afflicted (NZBxNZW)F1 mice with hCDR1 (once a week for 10weeks). The treatment resulted in the up-regulation of neurogenesis in the dentate gyrus and restored the NeuN immunoreactivity in brain hippocampi of the mice in association with increased gene expression of IGF-1, NGF and BDNF. Furthermore, hCDR1 treatment significantly up-regulated p-ERK and p-Akt that are suggested to be key components in mediating growth factor-induced neurogenesis. The observed effects of hCDR1 on hippocampal-neurogenesis and on associated signaling pathways suggest a potential role for hCDR1 in CNS lupus.
为了确定耐受肽 hCDR1 对海马神经发生的影响，我们用 hCDR1 治疗 SLE 发病（NZBxNZW）F1 小鼠（每周一次，共 10 周）。该治疗导致齿状回的神经发生上调，并恢复了与 IGF-1、NGF 和 BDNF 基因表达增加相关的小鼠大脑海马的 NeuN 免疫反应性。此外，hCDR1 治疗显著上调了 p-ERK 和 p-Akt，这被认为是介导生长因子诱导的神经发生的关键成分。hCDR1 对海马神经发生及其相关信号通路的观察到的影响表明 hCDR1 在中枢神经系统狼疮中可能具有作用。
