E6 分子变异型人乳头瘤病毒（HPV）16 型：聚类和命名的更新和统一标准。

E6 molecular variants of human papillomavirus (HPV) type 16: an updated and unified criterion for clustering and nomenclature.

机构信息

Grupo investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Calle 1 # 9 - 85, Bogotá D.C., Colombia.

出版信息

Virology. 2011 Feb 5;410(1):201-15. doi: 10.1016/j.virol.2010.10.039. Epub 2010 Dec 4.

DOI:10.1016/j.virol.2010.10.039

PMID:21130481

Abstract

Reports on taxonomic identification of E6/HPV 16 variants, don't have a worldwide, updated and unified criterion for clustering and nomenclature. Our aim was to update the existing criterion and propose a new one for clustering and nomenclature for E6/HPV 16 molecular variants based on the descriptive and comparative analyses of nucleotide sequences. A systematic search of the publications between 1991 and 2010 was carried out in PUBMED and manually. 240 E6/HPV 16 variants were identified. 157 were classified as European (E), 24 as Asian (As), 14 as Asian American (AA), 11 as North American 1 (NA 1), 19 as African 1 (Af 1) and 15 as African 2 (Af 2). Three classes were determined for the E, 3 each for the As, Af 2 and AA branches, 4 classes for the NA 1 and 6 for the Af 1 branch. This study reports our results and proposes an updated criterion for clustering and nomenclature that will be useful for E6 variant identification.

摘要

关于 E6/HPV16 变体分类鉴定的报告，目前尚无全球范围的、更新的和统一的聚类和命名标准。我们旨在更新现有的标准，并根据核苷酸序列的描述性和比较分析，为 E6/HPV16 分子变体的聚类和命名提出一个新的标准。在 PUBMED 中进行了 1991 年至 2010 年的文献系统检索，并进行了手动检索。共鉴定出 240 种 E6/HPV16 变体。其中 157 种被归类为欧洲型（E），24 种为亚洲型（As），14 种为亚洲裔美国型（AA），11 种为北美 1 型（NA1），19 种为非洲 1 型（Af1），15 种为非洲 2 型（Af2）。E 型确定了 3 个类，As、Af2 和 AA 分支各确定了 3 个类，NA1 有 4 个类，Af1 有 6 个类。本研究报告了我们的结果，并提出了一个更新的聚类和命名标准，这将有助于 E6 变体的鉴定。