2022 - 2023年伊朗德黑兰16型人乳头瘤病毒的谱系和亚谱系调查：一项横断面研究
The Lineage and Sublineage Investigation of Human Papillomavirus Type 16 in Tehran, Iran, During 2022-2023: A Cross-Sectional Study.
作者信息
Khezeli Zohreh, Shoja Zabihollah, Kaffashian Mehrnaz, Soleimani-Jelodar Rahim, Jalilvand Somayeh
机构信息
Department of Virology, School of Public Health Tehran University of Medical Sciences Tehran Iran.
Department of Virology Pasteur Institute of Iran Tehran Iran.
出版信息
Health Sci Rep. 2025 May 5;8(5):e70680. doi: 10.1002/hsr2.70680. eCollection 2025 May.
BACKGROUND AND AIMS
Diverse HPV 16 variants have been known to vary in geographic distribution and oncogenic potential. On this point, the nucleotide changes of the E6 gene were studied to find lineages of HPV 16 in normal, premalignant, and malignant stages of uterine cervical samples.
METHODS
In this study, 120 HPV 16-infected samples were investigated using PCR and sequencing.
RESULTS
In our samples, three lineages A, C, and D were found and lineage D was predominant (79.2%) followed by lineages A (20%) and C (0.8%). Concerning the association between histopathological stages and lineages, no statistically important differences were found.
CONCLUSION
Our finding revealed that two lineages A and D were circulating, with the dominancy of lineage, in Tehran, Iran. This finding emphasizes the geographic diversity of distinct HPV 16 (sub)lineages is different in the world.
背景与目的
已知多种HPV 16变体在地理分布和致癌潜力方面存在差异。基于此，研究了E6基因的核苷酸变化，以寻找子宫颈样本正常、癌前和恶性阶段的HPV 16谱系。
方法
在本研究中，使用PCR和测序对120个HPV 16感染样本进行了调查。
结果
在我们的样本中，发现了A、C和D三个谱系，其中D谱系占主导（79.2%），其次是A谱系（20%）和C谱系（0.8%）。关于组织病理学阶段与谱系之间的关联，未发现统计学上的显著差异。
结论
我们的研究结果表明，在伊朗德黑兰，A和D两个谱系在流行，且D谱系占主导。这一发现强调了不同HPV 16（亚）谱系在世界范围内的地理多样性。
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