Howard Hughes Medical Institute, Developmental Biology Program, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
Curr Opin Cell Biol. 2011 Feb;23(1):30-8. doi: 10.1016/j.ceb.2010.10.014. Epub 2010 Dec 3.
Contractile actin-myosin networks generate forces that drive cell shape changes and tissue remodeling during development. These forces can also actively regulate cell signaling and behavior. Novel features of actin-myosin network dynamics, such as pulsed contractile behaviors and the regulation of myosin localization by tension, have been uncovered in recent studies of Drosophila. In vitro studies of single molecules and reconstituted protein networks reveal intrinsic properties of motor proteins and actin-myosin networks, while in vivo studies have provided insight into the regulation of their dynamics and organization. Analysis of the complex behaviors of actin-myosin networks will be crucial for understanding force generation in actively remodeling cells and the coordination of cell shape and movement at the tissue level.
收缩性肌动球蛋白网络产生的力在发育过程中驱动细胞形状变化和组织重塑。这些力还可以主动调节细胞信号转导和行为。最近对果蝇的研究揭示了肌动球蛋白网络动力学的一些新特征，如脉冲收缩行为和张力对肌球蛋白定位的调节。体外对单个分子和重组蛋白网络的研究揭示了运动蛋白和肌动球蛋白网络的固有特性，而体内研究则提供了对其动力学和组织调节的深入了解。分析肌动球蛋白网络的复杂行为对于理解活跃重塑细胞中的力生成以及组织水平上细胞形状和运动的协调至关重要。
