Institute for Biophysical Dynamics and James Franck Institute, University of Chicago, Chicago, IL 60637, USA.
Curr Opin Cell Biol. 2010 Oct;22(5):583-8. doi: 10.1016/j.ceb.2010.07.010. Epub 2010 Aug 20.
Adhesions are a central mechanism by which cells mechanically interact with the surrounding extracellular matrix (ECM) and neighboring cells. In both cell-ECM and cell-cell adhesions, forces generated within the actin cytoskeleton are transmitted to the surrounding environment and are essential for numerous morphogenic processes. Despite differences in many molecular components that regulate cell-cell and cell-ECM adhesions, the roles of F-actin dynamics and mechanical forces in adhesion regulation are surprisingly similar. Moreover, force transmission at adhesions occurs concomitantly with dynamic F-actin; proteins comprising the adhesion of F-actin to the plasma membrane must accommodate this movement while still facilitating force transmission. Thus, despite different molecular architectures, integrin and cadherin-mediated adhesions operate with common biophysical characteristics to transmit and respond to mechanical forces in multicellular tissue.
粘连是细胞与周围细胞外基质（ECM）和邻近细胞机械相互作用的核心机制。在细胞-ECM 和细胞-细胞黏附中，肌动蛋白细胞骨架内产生的力被传递到周围环境，对于许多形态发生过程是必不可少的。尽管调节细胞-细胞和细胞-ECM 黏附的许多分子成分存在差异，但 F-肌动蛋白动力学和机械力在黏附调节中的作用惊人地相似。此外，黏附处的力传递与动态 F-肌动蛋白同时发生；构成 F-肌动蛋白与质膜黏附的蛋白质必须适应这种运动，同时仍然促进力的传递。因此，尽管分子结构不同，整合素和钙黏蛋白介导的黏附以共同的生物物理特性发挥作用，以在多细胞组织中传递和响应机械力。
