Department of Neurology, Wendeng Center Hospital of Weihai, The Affiliated Hospital of Weifang Medical College, Shandong Province 264400, PR China.
Biochem Biophys Res Commun. 2011 Jan 7;404(1):6-9. doi: 10.1016/j.bbrc.2010.11.113. Epub 2010 Dec 3.
Hydrogen sulfide (H(2)S) has been recognized as a toxic gas and environment pollutant. So, it is seldom regarded as a therapeutic gas. H(2)S has been recognized recently as a novel gaseous messenger and serves as an important neuromodulator in the central nervous system. Many researches have been focused on the protective role of H(2)S in treatment of several diseases. Like nitric oxide (NO) and carbon monoxide (CO), which are considered as two gaseous transmitters, H(2)S has been regarded as the third one. Recent studies provided evidence that H(2)S exerted antioxidant and anti-apoptotic effects, which protected neurons, cardiomyocytes, pancreatic β-cells and vascular smooth muscle cells against oxidative stress by scavenging reactive oxygen species (ROS) and reactive nitrogen species (RNS). It has been known that multiple factors, including oxidative stress, free radicals and neuronal nitric oxide syntheses as well as abnormal inflammatory responses are involved in the mechanism underlying the brain injury after acute CO poisoning. Studies have shown that free radical scavengers can display neuroprotective properties. Therefore, we hypothesize that H(2)S might be an interesting potential strategy for curing acute CO poisoning.
硫化氢 (H(2)S) 已被认为是一种有毒气体和环境污染物。因此，它很少被视为治疗气体。最近，H(2)S 被认为是一种新型气体信使，并作为中枢神经系统中的重要神经调节剂。许多研究集中在 H(2)S 在治疗几种疾病中的保护作用上。与被认为是两种气体递质的一氧化氮 (NO) 和一氧化碳 (CO) 一样，H(2)S 被认为是第三种。最近的研究提供了证据表明，H(2)S 发挥抗氧化和抗细胞凋亡作用，通过清除活性氧 (ROS) 和活性氮 (RNS) 来保护神经元、心肌细胞、胰岛 β 细胞和血管平滑肌细胞免受氧化应激。已知多种因素，包括氧化应激、自由基和神经元一氧化氮合成以及异常的炎症反应，都参与了急性 CO 中毒后脑损伤的机制。研究表明，自由基清除剂具有神经保护作用。因此，我们假设 H(2)S 可能是治疗急性 CO 中毒的一种有趣的潜在策略。
