University of Jyväskylä, Department of Chemistry, University of Jyväskylä, Finland.
Steroids. 2011 Feb;76(3):261-8. doi: 10.1016/j.steroids.2010.11.007. Epub 2010 Dec 3.
Microwave (MW) assisted synthesis and solid state structural characterizations of novel lithocholyl amides of 2-, 3-, and 4-aminopyridine are reported. It is shown that the MW technique is a proper method in the preparation of N-lithocholyl amides of isomeric aminopyridines. It offers many advantages compared to conventional heating. The molecular and crystal structures as well as the polymorphic and hydrated forms of prepared conjugates with their thermodynamic stabilities have been characterized by means of high resolution liquid- and solid-state NMR spectroscopy, single crystal and powder X-ray diffraction, and thermogravimetric analysis. Owing to the many biological functions of bile acids and amino substituted nitrogen heterocycles, knowledge of the crystal packing of these novel conjugates may have relevance for potential pharmaceutical applications.
微波辅助合成及新型胆酰基 2-、3-和 4-氨基吡啶酰胺的固态结构特征研究。研究表明，微波技术是制备异质氨基吡啶 N-胆酰基酰胺的一种合适方法。与传统加热相比，它具有许多优点。通过高分辨率液-固核磁共振波谱、单晶和粉末 X 射线衍射以及热重分析，对所制备的共轭物的分子和晶体结构以及其多晶型和水合形式及其热力学稳定性进行了表征。由于胆汁酸和氨基取代的氮杂环具有许多生物学功能，这些新型共轭物的晶体堆积知识可能与潜在的药物应用有关。
